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人盲腸癌細(xì)胞(LS513)

￥800.00元

細(xì)胞貨號： CL0682

細(xì)胞種屬： 人源細(xì)胞系

細(xì)胞別名： LS-513; LS 513

發(fā)貨規(guī)格： 1×10?

供體信息： 63歲白人男性

腫瘤類型： Dukes' type C腺癌

組織來源： 盲腸

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背景信息

種屬：人源細(xì)胞系
組織來源：盲腸
腫瘤類型： Dukes' type C腺癌
供體信息： 63歲白人男性
背景描述：結(jié)直腸癌細(xì)胞系 LS-513 于 1985 年從一名 63 歲的白人男性患者的原發(fā)性腫瘤活檢中分離出來。他被診斷出患有位于 Bauhin 瓣膜的 Dukes C 粘蛋白分泌盲腸腫瘤。LS-513 細(xì)胞表達(dá)主要組織相容性（MHC） I 類抗原 HLA 和 β2 微球蛋白。MHC II 類抗原（未檢測到 HLA-DR、DQ 和 DP）。TGF β-1 抑制 LS-513 細(xì)胞的增殖，而 TGF β-2 對這些細(xì)胞的生長沒有影響。LS-513 細(xì)胞對 TGF β-1 的敏感性比 LS-1034 細(xì)胞系低 100 倍。LS-513 細(xì)胞具有多重耐藥性（MDR），在裸鼠中具有致瘤性。

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其他信息

蛋白表達(dá)： CEA+ (50%), p53+
基因表達(dá)： transforming growth factor beta 1 (TGF beta-1, 83 pg per 10^6 cells per 24 hours)
致癌基因： p53+ (wild-type)
致瘤性： Yes, forms tumors in nude mice
抗原表達(dá)： Carcinoembryonic antigen (CEA), ICAM-1, HLA class I positive
核型： Two stem lines can be distinguished. The main one was represented in 65% of the cells, with a modal number of 51,xY and 3 markers, M1 - der(1)t(1,15), M2 - der(2)t(2,3)der(3)t(2,3), M3, and a monosomy 15. The second stem line had a modal chromosome number of 52,xY and presented M2 and M3 plus an isochromosome for the long arm of chromosome 1 called M4. A trisomy 5,7, a tetrasomy 13, and a monosomy 2 and 3 were present in all of the cells analyzed, the line did not exhibit monosomy 15.

人盲腸癌細(xì)胞

Catalog No CL0682

Product information

蛋白表達(dá)： CEA+ (50%), p53+
基因表達(dá)： transforming growth factor beta 1 (TGF beta-1, 83 pg per 10^6 cells per 24 hours)
致癌基因： p53+ (wild-type)
致瘤性： Yes, forms tumors in nude mice
抗原表達(dá)： Carcinoembryonic antigen (CEA), ICAM-1, HLA class I positive
核型： Two stem lines can be distinguished. The main one was represented in 65% of the cells, with a modal number of 51,xY and 3 markers, M1 - der(1)t(1,15), M2 - der(2)t(2,3)der(3)t(2,3), M3, and a monosomy 15. The second stem line had a modal chromosome number of 52,xY and presented M2 and M3 plus an isochromosome for the long arm of chromosome 1 called M4. A trisomy 5,7, a tetrasomy 13, and a monosomy 2 and 3 were present in all of the cells analyzed, the line did not exhibit monosomy 15.

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