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APC Rabbit mAb

商品貨號： PRM8871

適應性： 人,小鼠,大鼠

￥800元

規(guī)格：

50ul

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說明書

商品描述

發(fā)貨日期：現(xiàn)貨
靶點-Target： APC
反應性-Reactivity：人,小鼠,大鼠
應用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 312kD
MW(Observed)： 160kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT1154R
特異性： Endogenous
基因名稱： APC
蛋白名稱： Adenomatous polyposis coli protein
別名： APC;DP2.5;Adenomatous polyposis coli protein;Protein APC;Deleted in polyposis 2.5
Organism-1： Human
基因ID-1： 324
SwissProt-1： P25054
Organism-2： Mouse
SwissProt-2： Q61315
Organism-3： Rat
基因ID-3： 24205
SwissProt-3： P70478
背景： This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008],
細胞定位： Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle membrane . Cytoplasm . Cell membrane . Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .

APC Rabbit mAb

Catalog No PRM8871

Product information

發(fā)貨日期：現(xiàn)貨
靶點-Target： APC
反應性-Reactivity：人,小鼠,大鼠
應用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 312kD
MW(Observed)： 160kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT1154R
特異性： Endogenous
基因名稱： APC
蛋白名稱： Adenomatous polyposis coli protein
別名： APC;DP2.5;Adenomatous polyposis coli protein;Protein APC;Deleted in polyposis 2.5
Organism-1： Human
基因ID-1： 324
SwissProt-1： P25054
Organism-2： Mouse
SwissProt-2： Q61315
Organism-3： Rat
基因ID-3： 24205
SwissProt-3： P70478
背景： This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008],
細胞定位： Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle membrane . Cytoplasm . Cell membrane . Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .

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