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GluR-2 Rabbit mAb

商品貨號： PRM8841

適應(yīng) 性： 人,小鼠,大鼠

￥800元

規(guī)格：

50ul

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MSDS

說明書

商品描述

發(fā)貨日期：現(xiàn)貨
靶點-Target： GluR-2
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 99kD
MW(Observed)： 99kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:10000-1:50000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT1058R
特異性： Endogenous
基因名稱： GRIA2 GLUR2
蛋白名稱： Glutamate receptor 2
別名： GRIA2;GLUR2;Glutamate receptor 2;GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic;AMPA 2;GluA2
Organism-1： Human
基因ID-1： 2891
SwissProt-1： P42262
Organism-2： Mouse
基因ID-2： 14800
SwissProt-2： P23819
Organism-3： Rat
基因ID-3： 29627
SwissProt-3： P19491
背景： Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco
細(xì)胞定位： Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). .

GluR-2 Rabbit mAb

Catalog No PRM8841

Product information

發(fā)貨日期：現(xiàn)貨
靶點-Target： GluR-2
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 99kD
MW(Observed)： 99kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:10000-1:50000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號： PT1058R
特異性： Endogenous
基因名稱： GRIA2 GLUR2
蛋白名稱： Glutamate receptor 2
別名： GRIA2;GLUR2;Glutamate receptor 2;GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic;AMPA 2;GluA2
Organism-1： Human
基因ID-1： 2891
SwissProt-1： P42262
Organism-2： Mouse
基因ID-2： 14800
SwissProt-2： P23819
Organism-3： Rat
基因ID-3： 29627
SwissProt-3： P19491
背景： Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco
細(xì)胞定位： Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). .

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