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YB-1 Rabbit mAb

商品貨號： PRM8720

適應(yīng) 性： 人,小鼠,大鼠

￥800元

規(guī)格：

50ul

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商品描述

發(fā)貨日期：現(xiàn)貨
靶點-Target： YB-1
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 36kD
MW(Observed)： 49kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG, Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號： PT1009R
特異性： Endogenous
基因名稱： YBX1
蛋白名稱： Nuclease-sensitive element-binding protein 1
別名： YBX1;NSEP1;YB1;Nuclease-sensitive element-binding protein 1;CCAAT-binding transcription factor I subunit A;CBF-A;DNA-binding protein B;DBPB;Enhancer factor I subunit A;EFI-A;Y-box transcription factor;Y-box-binding protein 1;YB-
Organism-1： Human
基因ID-1： 4904
SwissProt-1： P67809
Organism-2： Mouse
基因ID-2： 22608
SwissProt-2： P62960
Organism-3： Rat
基因ID-3： 500538
SwissProt-3： P62961
背景： This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015],
細(xì)胞定位： Cytoplasm . Nucleus . Cytoplasmic granule . Secreted . Secreted, extracellular exosome . Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673). .

YB-1 Rabbit mAb

Catalog No PRM8720

Product information

發(fā)貨日期：現(xiàn)貨
靶點-Target： YB-1
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 36kD
MW(Observed)： 49kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG, Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號： PT1009R
特異性： Endogenous
基因名稱： YBX1
蛋白名稱： Nuclease-sensitive element-binding protein 1
別名： YBX1;NSEP1;YB1;Nuclease-sensitive element-binding protein 1;CCAAT-binding transcription factor I subunit A;CBF-A;DNA-binding protein B;DBPB;Enhancer factor I subunit A;EFI-A;Y-box transcription factor;Y-box-binding protein 1;YB-
Organism-1： Human
基因ID-1： 4904
SwissProt-1： P67809
Organism-2： Mouse
基因ID-2： 22608
SwissProt-2： P62960
Organism-3： Rat
基因ID-3： 500538
SwissProt-3： P62961
背景： This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015],
細(xì)胞定位： Cytoplasm . Nucleus . Cytoplasmic granule . Secreted . Secreted, extracellular exosome . Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673). .

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