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BRCA1 Rabbit mAb

商品貨號(hào)： PRM8649

適應(yīng) 性： 人,

￥7000元

規(guī)格：

500ul

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： BRCA1
反應(yīng)性-Reactivity：人,
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 208kD
MW(Observed)： 270kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:10000-1:50000;WB 1:100-1:500;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào)： PT0876R
特異性： Endogenous
基因名稱： BRCA1
蛋白名稱： Breast cancer type 1 susceptibility protein
別名： BRCA1;RNF53;Breast cancer type 1 susceptibility protein;RING finger protein 53
Organism-1： Human
基因ID-1： 672
SwissProt-1： P38398
Organism-2： Mouse
SwissProt-2： P48754
Organism-3： Rat
基因ID-3： 497672
SwissProt-3： O54952
背景： This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
細(xì)胞定位： Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). .; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm .

BRCA1 Rabbit mAb

Catalog No PRM8649

Product information

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： BRCA1
反應(yīng)性-Reactivity：人,
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 208kD
MW(Observed)： 270kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:10000-1:50000;WB 1:100-1:500;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào)： PT0876R
特異性： Endogenous
基因名稱： BRCA1
蛋白名稱： Breast cancer type 1 susceptibility protein
別名： BRCA1;RNF53;Breast cancer type 1 susceptibility protein;RING finger protein 53
Organism-1： Human
基因ID-1： 672
SwissProt-1： P38398
Organism-2： Mouse
SwissProt-2： P48754
Organism-3： Rat
基因ID-3： 497672
SwissProt-3： O54952
背景： This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
細(xì)胞定位： Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). .; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm .

Hunan UPT Biotechnology Co.,Ltd

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