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IRF3 (Phospho Ser396) Rabbit mAb

商品貨號： PRM8648

適應(yīng) 性： 人,小鼠

￥7000元

規(guī)格：

500ul

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說明書

商品描述

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： IRF-3
反應(yīng)性-Reactivity：人,小鼠
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 47kD
MW(Observed)： 60kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Phospho
修飾-Modification： Ser396
推薦稀釋比： WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號： PT0875R
特異性： IRF3 (Phospho Ser396) Antibody detects endogenous levels of IRF3 protein only when phosphorylated at S396.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HIsNS
基因名稱： IRF3
蛋白名稱： Interferon regulatory factor 3
別名： IRF3;Interferon regulatory factor 3;IRF-3
Organism-1： Human
基因ID-1： 3661
SwissProt-1： Q14653
Organism-2： Mouse
基因ID-2： 54131
SwissProt-2： P70671
背景： This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
細(xì)胞定位： Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .

IRF3 (Phospho Ser396) Rabbit mAb

Catalog No PRM8648

Product information

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： IRF-3
反應(yīng)性-Reactivity：人,小鼠
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 47kD
MW(Observed)： 60kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Phospho
修飾-Modification： Ser396
推薦稀釋比： WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號： PT0875R
特異性： IRF3 (Phospho Ser396) Antibody detects endogenous levels of IRF3 protein only when phosphorylated at S396.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HIsNS
基因名稱： IRF3
蛋白名稱： Interferon regulatory factor 3
別名： IRF3;Interferon regulatory factor 3;IRF-3
Organism-1： Human
基因ID-1： 3661
SwissProt-1： Q14653
Organism-2： Mouse
基因ID-2： 54131
SwissProt-2： P70671
背景： This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
細(xì)胞定位： Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .

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