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CDKN2A/p14ARF Rabbit mAb

商品貨號(hào)： PRM8580

適應(yīng) 性： 人,

￥800元

規(guī)格：

50ul

在線咨詢(xún)

MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： p14ARF
反應(yīng)性-Reactivity：人,
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 14kD
MW(Observed)： 16kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號(hào)： PT0332R
特異性： Endogenous
基因名稱(chēng)： CDKN2A
蛋白名稱(chēng)： Cyclin-dependent kinase inhibitor 2A isoform 4
別名： CDKN2A;CDKN2;MLM;Cyclin-dependent kinase inhibitor 2A;isoform 4;p14ARF;p19ARF
Organism-1： Human
基因ID-1： 1029
SwissProt-1： Q8N726
Organism-2： Mouse
SwissProt-2： Q64364
背景： CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
細(xì)胞定位： Nuclear

CDKN2A/p14ARF Rabbit mAb

Catalog No PRM8580

Product information

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： p14ARF
反應(yīng)性-Reactivity：人,
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 14kD
MW(Observed)： 16kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號(hào)： PT0332R
特異性： Endogenous
基因名稱(chēng)： CDKN2A
蛋白名稱(chēng)： Cyclin-dependent kinase inhibitor 2A isoform 4
別名： CDKN2A;CDKN2;MLM;Cyclin-dependent kinase inhibitor 2A;isoform 4;p14ARF;p19ARF
Organism-1： Human
基因ID-1： 1029
SwissProt-1： Q8N726
Organism-2： Mouse
SwissProt-2： Q64364
背景： CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
細(xì)胞定位： Nuclear

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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