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Calreticulin Rabbit mAb

商品貨號(hào)： PRM8537

適應(yīng) 性： 人,小鼠,大鼠

￥800元

規(guī)格：

50ul

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說(shuō)明書(shū)

商品描述

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： Calregulin
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 48kD
MW(Observed)： 55kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號(hào)： PT0256R
特異性： Endogenous
基因名稱： CALR
蛋白名稱： Calreticulin
別名： CALR;CRTC;Calreticulin;CRP55;Calregulin;Endoplasmic reticulum resident protein 60;ERp60;HACBP;grp60
Organism-1： Human
基因ID-1： 811
SwissProt-1： P27797
Organism-2： Mouse
基因ID-2： 12317
SwissProt-2： P14211
Organism-3： Rat
基因ID-3： 64202
SwissProt-3： P18418
背景： Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its
細(xì)胞定位： Cytoplasm

Calreticulin Rabbit mAb

Catalog No PRM8537

Product information

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： Calregulin
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
MW(Calculated)： 48kD
MW(Observed)： 55kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG,Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆性： Monoclonal
克隆號(hào)： PT0256R
特異性： Endogenous
基因名稱： CALR
蛋白名稱： Calreticulin
別名： CALR;CRTC;Calreticulin;CRP55;Calregulin;Endoplasmic reticulum resident protein 60;ERp60;HACBP;grp60
Organism-1： Human
基因ID-1： 811
SwissProt-1： P27797
Organism-2： Mouse
基因ID-2： 12317
SwissProt-2： P14211
Organism-3： Rat
基因ID-3： 64202
SwissProt-3： P18418
背景： Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its
細(xì)胞定位： Cytoplasm

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