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Histone H2A (Acetyl Lys15) Polyclonal Antibody

商品貨號(hào)： PLN000196

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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說(shuō)明書(shū)

商品描述

基因名稱： HIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM/HIST2H2AA3/HIST2H2AA4/HIST3H2A
蛋白名稱： Histone H2A type 1/Histone H2A type 2/Histone H2A type 3
Human_gene_id： 8329/8330/8332/8336/8969/723790/8337/92815
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8329
Human_swiss_prot_no： P0C0S8/Q6FI13/Q7L7L0
Human_swiss_link： http://www.uniprot.org/uniprotkb/P0C0S8/entry
Mouse_gene_id： 319164/15267/319162
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319164
Rat_gene_id： 365877/64646
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=365877
Rat_swiss_prot_no： P02262/P0CC09/Q4FZT6
Rat_swiss_link： http://www.uniprot.org/uniprot/P02262
特異性： The antibody detects endogenous Histone H2A (Acetyl Lys15) protein.
組成： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-1000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p; HIST2H2AA3; H2AFO; HIST2H2AA; HIST2H2AA4; Histone H2A type 2-A; Histone H2A.2; Histone H2A/o; HIST3H2A; Histone H2A type 3;H2AK15AC
實(shí)測(cè)條帶： 14kD
信號(hào)通路： Systemic lupus erythematosus;
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.,PTM:Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.,PTM:Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.,PTM:The chromatin-associated form is phosphorylated on Thr-121 during mitosis.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome.
組織表達(dá)： Bone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple
科研貨號(hào)： PLN000196

Histone H2A (Acetyl Lys15) Polyclonal Antibody

Catalog No PLN000196

Product information

基因名稱： HIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM/HIST2H2AA3/HIST2H2AA4/HIST3H2A
蛋白名稱： Histone H2A type 1/Histone H2A type 2/Histone H2A type 3
Human_gene_id： 8329/8330/8332/8336/8969/723790/8337/92815
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8329
Human_swiss_prot_no： P0C0S8/Q6FI13/Q7L7L0
Human_swiss_link： http://www.uniprot.org/uniprotkb/P0C0S8/entry
Mouse_gene_id： 319164/15267/319162
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319164
Rat_gene_id： 365877/64646
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=365877
Rat_swiss_prot_no： P02262/P0CC09/Q4FZT6
Rat_swiss_link： http://www.uniprot.org/uniprot/P02262
特異性： The antibody detects endogenous Histone H2A (Acetyl Lys15) protein.
組成： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-1000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p; HIST2H2AA3; H2AFO; HIST2H2AA; HIST2H2AA4; Histone H2A type 2-A; Histone H2A.2; Histone H2A/o; HIST3H2A; Histone H2A type 3;H2AK15AC
實(shí)測(cè)條帶： 14kD
信號(hào)通路： Systemic lupus erythematosus;
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.,PTM:Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.,PTM:Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.,PTM:The chromatin-associated form is phosphorylated on Thr-121 during mitosis.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome.
組織表達(dá)： Bone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple
科研貨號(hào)： PLN000196

Hunan UPT Biotechnology Co.,Ltd

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