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NCoA-3 (Acetyl Lys616) rabbit pAb

商品貨號(hào)： PLN000171

適應(yīng) 性： 人,大鼠,小鼠,

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

基因名稱(chēng)： NCOA3 AIB1 BHLHE42 RAC3 TRAM1
蛋白名稱(chēng)： NCoA-3 (Acetyl Lys616)
Human_gene_id： 8202
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8202
Human_swiss_prot_no： Q9Y6Q9
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9Y6Q9/entry
Mouse_gene_link： https://www.uniprot.org/uniprot/0
Mouse_swiss_prot_no： O09000
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O09000
Rat_swiss_prot_no： Q9EPU2
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q9EPU2
特異性： This antibody detects endogenous levels of Human NCoA-3 (Acetyl Lys616)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋?zhuān)? WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： Nuclear receptor coactivator 3 (NCoA-3;EC 2.3.1.48;ACTR;Amplified in breast cancer 1 protein;AIB-1;CBP-interacting protein;pCIP;Class E basic helix-loop-helix protein 42;bHLHe42;Receptor-associated coactivator 3;RAC-3;Steroid receptor coactivator protein 3;SRC-3;Thyroid hormone receptor activator molecule 1;TRAM-1)
實(shí)測(cè)條帶： 160kD
功能： alternative products:Additional isoforms seem to exist,catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,domain:Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).,enzyme regulation:Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors.,function:Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.,miscellaneous:NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.,polymorphism:The length of the poly-Gln region is polymorphic in the normal population.,PTM:Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.,PTM:Methylated by CARM1.,PTM:Phosphorylated by IKK complex. Regulated its function.,similarity:Belongs to the SRC/p160 nuclear receptor coactivator family.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subcellular location:Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.,subunit:Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol.,tissue specificity:Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3211
細(xì)胞定位： Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
組織表達(dá)： Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
科研貨號(hào)： PLN000171

NCoA-3 (Acetyl Lys616) rabbit pAb

Catalog No PLN000171

Product information

基因名稱(chēng)： NCOA3 AIB1 BHLHE42 RAC3 TRAM1
蛋白名稱(chēng)： NCoA-3 (Acetyl Lys616)
Human_gene_id： 8202
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8202
Human_swiss_prot_no： Q9Y6Q9
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9Y6Q9/entry
Mouse_gene_link： https://www.uniprot.org/uniprot/0
Mouse_swiss_prot_no： O09000
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O09000
Rat_swiss_prot_no： Q9EPU2
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q9EPU2
特異性： This antibody detects endogenous levels of Human NCoA-3 (Acetyl Lys616)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋?zhuān)? WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： Nuclear receptor coactivator 3 (NCoA-3;EC 2.3.1.48;ACTR;Amplified in breast cancer 1 protein;AIB-1;CBP-interacting protein;pCIP;Class E basic helix-loop-helix protein 42;bHLHe42;Receptor-associated coactivator 3;RAC-3;Steroid receptor coactivator protein 3;SRC-3;Thyroid hormone receptor activator molecule 1;TRAM-1)
實(shí)測(cè)條帶： 160kD
功能： alternative products:Additional isoforms seem to exist,catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,domain:Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).,enzyme regulation:Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors.,function:Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.,miscellaneous:NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.,polymorphism:The length of the poly-Gln region is polymorphic in the normal population.,PTM:Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.,PTM:Methylated by CARM1.,PTM:Phosphorylated by IKK complex. Regulated its function.,similarity:Belongs to the SRC/p160 nuclear receptor coactivator family.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subcellular location:Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.,subunit:Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol.,tissue specificity:Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3211
細(xì)胞定位： Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
組織表達(dá)： Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
科研貨號(hào)： PLN000171

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