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Smad7 (Acetyl Lys70) rabbit pAb

商品貨號(hào)： PLN000168

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

基因名稱： SMAD7 MADH7 MADH8
蛋白名稱： Smad7 (Acetyl Lys70)
Human_gene_id： 4092
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4092
Human_swiss_prot_no： O15105
Human_swiss_link： https://www.uniprot.org/uniprotkb/O15105/entry
Mouse_gene_id： 17131
Mouse_gene_link： https://www.uniprot.org/uniprot/17131
Mouse_swiss_prot_no： O35253
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O35253
Rat_gene_id： 81516
Rat_gene_link： https://www.uniprot.org/uniprot/81516
Rat_swiss_prot_no： O88406
Rat_swiss_link： https://www.uniprot.org/uniprotkb/O88406
特異性： This antibody detects endogenous levels of Human,Mouse,Rat Smad7 (Acetyl Lys70)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Mothers against decapentaplegic homolog 7 (MAD homolog 7;Mothers against DPP homolog 7;Mothers against decapentaplegic homolog 8;MAD homolog 8;Mothers against DPP homolog 8;SMAD family member 7;SMAD 7;Smad7;hSMAD7)
分子量： 47kD
功能： disease:Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3) [MIM:612229]. Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber.,function:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.,induction:By TGF-beta.,PTM:Acetylation prevents ubiquitination and degradation mediated by SMURF1.,PTM:Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription.,PTM:Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.,subunit:Interacts with TGF-beta type I receptor. Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with SMURF2.,tissue specificity:Ubiquitous with higher expression in the lung and vascular endothelium.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3208
細(xì)胞定位： Nucleus . Cytoplasm . Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). .
組織表達(dá)： Ubiquitous with higher expression in the lung and vascular endothelium.
科研貨號(hào)： PLN000168

Smad7 (Acetyl Lys70) rabbit pAb

Catalog No PLN000168

Product information

基因名稱： SMAD7 MADH7 MADH8
蛋白名稱： Smad7 (Acetyl Lys70)
Human_gene_id： 4092
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4092
Human_swiss_prot_no： O15105
Human_swiss_link： https://www.uniprot.org/uniprotkb/O15105/entry
Mouse_gene_id： 17131
Mouse_gene_link： https://www.uniprot.org/uniprot/17131
Mouse_swiss_prot_no： O35253
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/O35253
Rat_gene_id： 81516
Rat_gene_link： https://www.uniprot.org/uniprot/81516
Rat_swiss_prot_no： O88406
Rat_swiss_link： https://www.uniprot.org/uniprotkb/O88406
特異性： This antibody detects endogenous levels of Human,Mouse,Rat Smad7 (Acetyl Lys70)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Mothers against decapentaplegic homolog 7 (MAD homolog 7;Mothers against DPP homolog 7;Mothers against decapentaplegic homolog 8;MAD homolog 8;Mothers against DPP homolog 8;SMAD family member 7;SMAD 7;Smad7;hSMAD7)
分子量： 47kD
功能： disease:Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3) [MIM:612229]. Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber.,function:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.,induction:By TGF-beta.,PTM:Acetylation prevents ubiquitination and degradation mediated by SMURF1.,PTM:Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription.,PTM:Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.,subunit:Interacts with TGF-beta type I receptor. Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with SMURF2.,tissue specificity:Ubiquitous with higher expression in the lung and vascular endothelium.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3208
細(xì)胞定位： Nucleus . Cytoplasm . Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). .
組織表達(dá)： Ubiquitous with higher expression in the lung and vascular endothelium.
科研貨號(hào)： PLN000168

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