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Histone H2A (Acetyl Lys6) rabbit pAb

商品貨號： PLN000116

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： HIST1H2AG H2AFP; HIST1H2AI H2AFC; HIST1H2AK H2AFD; HIST1H2AL H2AFI; HIST1H2AM H2AFN
蛋白名稱： Histone H2A (Acetyl Lys6)
Human_gene_id： 8329
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8329
Human_swiss_prot_no： P0C0S8
Human_swiss_link： https://www.uniprot.org/uniprotkb/P0C0S8/entry
Mouse_gene_id： 319164
Mouse_gene_link： https://www.uniprot.org/uniprot/319164
Mouse_swiss_prot_no： P22752
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P22752
Rat_swiss_prot_no： P02262
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P02262
特異性： This antibody detects endogenous levels of Human,Mouse,Rat Histone H2A (Acetyl Lys6)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Histone H2A type 1 (H2A.1;Histone H2A/p)
實(shí)測條帶： 15kD
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.,PTM:Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.,PTM:Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.,PTM:The chromatin-associated form is phosphorylated on Thr-121 during mitosis.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3155
細(xì)胞定位： Nucleus. Chromosome.
科研貨號： PLN000116

Histone H2A (Acetyl Lys6) rabbit pAb

Catalog No PLN000116

Product information

基因名稱： HIST1H2AG H2AFP; HIST1H2AI H2AFC; HIST1H2AK H2AFD; HIST1H2AL H2AFI; HIST1H2AM H2AFN
蛋白名稱： Histone H2A (Acetyl Lys6)
Human_gene_id： 8329
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8329
Human_swiss_prot_no： P0C0S8
Human_swiss_link： https://www.uniprot.org/uniprotkb/P0C0S8/entry
Mouse_gene_id： 319164
Mouse_gene_link： https://www.uniprot.org/uniprot/319164
Mouse_swiss_prot_no： P22752
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P22752
Rat_swiss_prot_no： P02262
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P02262
特異性： This antibody detects endogenous levels of Human,Mouse,Rat Histone H2A (Acetyl Lys6)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Histone H2A type 1 (H2A.1;Histone H2A/p)
實(shí)測條帶： 15kD
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.,PTM:Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.,PTM:Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.,PTM:The chromatin-associated form is phosphorylated on Thr-121 during mitosis.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3155
細(xì)胞定位： Nucleus. Chromosome.
科研貨號： PLN000116

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