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HNF-4α/γ (Acetyl Lys127/79) Polyclonal Antibody

商品貨號(hào)： PLN000082

適應(yīng) 性： 人,小鼠,大鼠,

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： HNF4A HNF4 NR2A1 TCF14 HNF4G NR2A2
蛋白名稱： Hepatocyte nuclear factor 4-alpha/gamma (HNF-4-alpha/gamma) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Human_gene_id： 3172
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3172
Human_swiss_prot_no： P41235/Q14541
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41235/entry
特異性： This antibody detects endogenous levels of HNF-4α/γ at Human:K127/79;Mouse:K127/79;Rat:K127, It doesn't reacte with total protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000, ELISA 1:10000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)(TCF-14) (Transcription factor HNF-4)
實(shí)測條帶： 55kD
信號(hào)通路： Maturity onset diabetes of the young;
功能： alternative products:Additional isoforms seem to exist,disease:Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM:125850]; also shortened MODY-1. MODY [MIM:606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.,function:Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.,miscellaneous:Binds fatty acids.,online information:Hepatocyte nuclear factors entry,PTM:Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimerization is required for HNF4-alpha to bind to its recognition site.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus.
組織表達(dá)： Kidney,Liver,
科研貨號(hào)： PLN000082

HNF-4α/γ (Acetyl Lys127/79) Polyclonal Antibody

Catalog No PLN000082

Product information

基因名稱： HNF4A HNF4 NR2A1 TCF14 HNF4G NR2A2
蛋白名稱： Hepatocyte nuclear factor 4-alpha/gamma (HNF-4-alpha/gamma) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Human_gene_id： 3172
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3172
Human_swiss_prot_no： P41235/Q14541
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41235/entry
特異性： This antibody detects endogenous levels of HNF-4α/γ at Human:K127/79;Mouse:K127/79;Rat:K127, It doesn't reacte with total protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000, ELISA 1:10000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)(TCF-14) (Transcription factor HNF-4)
實(shí)測條帶： 55kD
信號(hào)通路： Maturity onset diabetes of the young;
功能： alternative products:Additional isoforms seem to exist,disease:Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM:125850]; also shortened MODY-1. MODY [MIM:606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.,function:Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.,miscellaneous:Binds fatty acids.,online information:Hepatocyte nuclear factors entry,PTM:Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimerization is required for HNF4-alpha to bind to its recognition site.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus.
組織表達(dá)： Kidney,Liver,
科研貨號(hào)： PLN000082

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