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E2F-1 (Acetyl Lys120) Polyclonal Antibody

商品貨號(hào)： PLN000074

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： E2F1 RBBP3
蛋白名稱： E2F transcription factor 1
Human_gene_id： 1869
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1869
Human_swiss_prot_no： Q01094
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q01094/entry
Mouse_swiss_prot_no： Q61501
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61501
Rat_swiss_prot_no： O09139
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941O09139
特異性： This antibody detects endogenous levels of E2F-1 at Human:K120;Mouse:K115;Rat:K118, It doesn't reacte with total protein.
組成： PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-10000 ELISA: 1:10000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： E2F1 RBBP3
實(shí)測條帶： 60kD
信號(hào)通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;
功能： function:Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.,PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.,similarity:Belongs to the E2F/DP family.,subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus .
組織表達(dá)： Brain,Epithelium,Pancreas,Skin,
科研貨號(hào)： PLN000074

E2F-1 (Acetyl Lys120) Polyclonal Antibody

Catalog No PLN000074

Product information

基因名稱： E2F1 RBBP3
蛋白名稱： E2F transcription factor 1
Human_gene_id： 1869
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1869
Human_swiss_prot_no： Q01094
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q01094/entry
Mouse_swiss_prot_no： Q61501
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61501
Rat_swiss_prot_no： O09139
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941O09139
特異性： This antibody detects endogenous levels of E2F-1 at Human:K120;Mouse:K115;Rat:K118, It doesn't reacte with total protein.
組成： PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-10000 ELISA: 1:10000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： E2F1 RBBP3
實(shí)測條帶： 60kD
信號(hào)通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;
功能： function:Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.,PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.,similarity:Belongs to the E2F/DP family.,subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus .
組織表達(dá)： Brain,Epithelium,Pancreas,Skin,
科研貨號(hào)： PLN000074

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.