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Acetyl-EPAS-1 (K385) Polyclonal Antibody

商品貨號： PLN000073

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： EPAS1 BHLHE73 HIF2A MOP2 PASD2
蛋白名稱： Acetyl-EPAS-1 (K385)
Human_gene_id： 2034
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2034
Human_swiss_prot_no： Q99814
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99814/entry
Mouse_swiss_prot_no： P97481
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97481
Rat_swiss_prot_no： Q9JHS1
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941Q9JHS1
特異性： Acetyl-EPAS-1 (K385) Polyclonal Antibody detects endogenous levels of Acetyl-EPAS-1 (K385)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000, ELISA 1:10000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： endothelial PAS domain protein 1
實測條帶： 120kD
信號通路： Pathways in cancer;Renal cell carcinoma;
功能： disease:Defects in EPAS1 are the cause of erythrocytosis familial type 4 (ECYT4) [MIM:611783]. ECYT4 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin concentration and hematocrit, and normal platelet and leukocyte counts.,function:Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.,PTM:In normoxia, is hydroxylated on Asn-847 by HIF1AN thus probably abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.,PTM:In normoxia, is probably hydroxylated on Pro-405 and Pro-531 by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization.,PTM:Phosphorylated on multiple sites in the CTAD.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP.,tissue specificity:Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles. .
組織表達： Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
科研貨號： PLN000073

Acetyl-EPAS-1 (K385) Polyclonal Antibody

Catalog No PLN000073

Product information

基因名稱： EPAS1 BHLHE73 HIF2A MOP2 PASD2
蛋白名稱： Acetyl-EPAS-1 (K385)
Human_gene_id： 2034
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2034
Human_swiss_prot_no： Q99814
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99814/entry
Mouse_swiss_prot_no： P97481
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97481
Rat_swiss_prot_no： Q9JHS1
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941Q9JHS1
特異性： Acetyl-EPAS-1 (K385) Polyclonal Antibody detects endogenous levels of Acetyl-EPAS-1 (K385)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000, ELISA 1:10000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： endothelial PAS domain protein 1
實測條帶： 120kD
信號通路： Pathways in cancer;Renal cell carcinoma;
功能： disease:Defects in EPAS1 are the cause of erythrocytosis familial type 4 (ECYT4) [MIM:611783]. ECYT4 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin concentration and hematocrit, and normal platelet and leukocyte counts.,function:Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.,PTM:In normoxia, is hydroxylated on Asn-847 by HIF1AN thus probably abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.,PTM:In normoxia, is probably hydroxylated on Pro-405 and Pro-531 by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization.,PTM:Phosphorylated on multiple sites in the CTAD.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP.,tissue specificity:Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles. .
組織表達： Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
科研貨號： PLN000073

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