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Stat3 (Acetyl Lys87) Polyclonal Antibody

商品貨號： PLN000070

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： STAT3
蛋白名稱： Signal transducer and activator of transcription 3
Human_gene_id： 6774
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6774
Human_swiss_prot_no： P40763
Human_swiss_link： http://www.uniprot.org/uniprotkb/P40763/entry
Mouse_gene_id： 20848
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20848
Mouse_swiss_prot_no： P42227
Mouse_swiss_link： http://www.uniprot.org/uniprot/P42227
Rat_gene_id： 25125
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25125
Rat_swiss_prot_no： P52631
Rat_swiss_link： http://www.uniprot.org/uniprot/P52631
特異性： Acetyl-Stat3 (K87) Polyclonal Antibody detects endogenous levels of Stat3 around the acetylation site of K87 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
實測條帶： 85kD
信號通路： Chemokine;Jak_STAT;Adipocytokine;Pathways in cancer;Pancreatic cancer;Acute myeloid leukemia;
功能： disease:Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.,function:Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.,miscellaneous:Involved in the gp130-mediated signaling pathway.,online information:STAT3 entry,online information:STAT3 mutation db,PTM:Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA. Interacts with SIPAR. Interacts (via SH2 domain) with NLK (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with TMF1.,tissue specificity:Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
相關(guān)產(chǎn)品： YT4445,YT4444,YT4443,YP0251,YP0250,YM3641,YM3507,YM3502,YM3451,YM3450,YK0070,KA3182C,KA3181C,KA3180C,KA1148C,KA1147C
細胞定位： Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
組織表達： Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).
tag： hot
科研貨號： PLN000070

Stat3 (Acetyl Lys87) Polyclonal Antibody

Catalog No PLN000070

Product information

基因名稱： STAT3
蛋白名稱： Signal transducer and activator of transcription 3
Human_gene_id： 6774
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6774
Human_swiss_prot_no： P40763
Human_swiss_link： http://www.uniprot.org/uniprotkb/P40763/entry
Mouse_gene_id： 20848
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20848
Mouse_swiss_prot_no： P42227
Mouse_swiss_link： http://www.uniprot.org/uniprot/P42227
Rat_gene_id： 25125
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25125
Rat_swiss_prot_no： P52631
Rat_swiss_link： http://www.uniprot.org/uniprot/P52631
特異性： Acetyl-Stat3 (K87) Polyclonal Antibody detects endogenous levels of Stat3 around the acetylation site of K87 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
實測條帶： 85kD
信號通路： Chemokine;Jak_STAT;Adipocytokine;Pathways in cancer;Pancreatic cancer;Acute myeloid leukemia;
功能： disease:Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.,function:Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.,miscellaneous:Involved in the gp130-mediated signaling pathway.,online information:STAT3 entry,online information:STAT3 mutation db,PTM:Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA. Interacts with SIPAR. Interacts (via SH2 domain) with NLK (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with TMF1.,tissue specificity:Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
相關(guān)產(chǎn)品： YT4445,YT4444,YT4443,YP0251,YP0250,YM3641,YM3507,YM3502,YM3451,YM3450,YK0070,KA3182C,KA3181C,KA3180C,KA1148C,KA1147C
細胞定位： Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
組織表達： Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).
tag： hot
科研貨號： PLN000070

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