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RIP140 (Acetyl Lys158) Polyclonal Antibody

商品貨號： PLN000069

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： NRIP1
蛋白名稱： Nuclear receptor-interacting protein 1
Human_gene_id： 8204
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8204
Human_swiss_prot_no： P48552
Human_swiss_link： http://www.uniprot.org/uniprotkb/P48552/entry
Mouse_gene_id： 268903
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268903
Mouse_swiss_prot_no： Q8CBD1
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8CBD1
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat_swiss_link： http://www.uniprot.org/uniprot/
特異性： Acetyl-RIP140 (K158) Polyclonal Antibody detects endogenous levels of RIP140 around the acetylation site of K158 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： NRIP1; Nuclear receptor-interacting protein 1; Nuclear factor RIP140; Receptor-interacting protein 140
功能： disease:Genetic variation in NRIP1 may act as predisposing factor for endometriosis.,domain:Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.,function:Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.,PTM:Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.,subcellular location:Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.,subunit:Interacts with the ligand binding domain (LBD) of NR2C1 in the absence of ligand. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
組織表達(dá)： Brain,Epithelium,Mammary gland,Skin,
tag： hot
科研貨號： PLN000069

RIP140 (Acetyl Lys158) Polyclonal Antibody

Catalog No PLN000069

Product information

基因名稱： NRIP1
蛋白名稱： Nuclear receptor-interacting protein 1
Human_gene_id： 8204
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8204
Human_swiss_prot_no： P48552
Human_swiss_link： http://www.uniprot.org/uniprotkb/P48552/entry
Mouse_gene_id： 268903
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268903
Mouse_swiss_prot_no： Q8CBD1
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8CBD1
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat_swiss_link： http://www.uniprot.org/uniprot/
特異性： Acetyl-RIP140 (K158) Polyclonal Antibody detects endogenous levels of RIP140 around the acetylation site of K158 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： NRIP1; Nuclear receptor-interacting protein 1; Nuclear factor RIP140; Receptor-interacting protein 140
功能： disease:Genetic variation in NRIP1 may act as predisposing factor for endometriosis.,domain:Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.,function:Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.,PTM:Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.,subcellular location:Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.,subunit:Interacts with the ligand binding domain (LBD) of NR2C1 in the absence of ligand. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
組織表達(dá)： Brain,Epithelium,Mammary gland,Skin,
tag： hot
科研貨號： PLN000069

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