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CRM1 (Acetyl Lys568) Polyclonal Antibody

商品貨號(hào)： PLN000058

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

基因名稱： XPO1
蛋白名稱： Exportin-1
Human_gene_id： 7514
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7514
Human_swiss_prot_no： O14980
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14980/entry
Mouse_gene_id： 103573
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103573
Mouse_swiss_prot_no： Q6P5F9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6P5F9
Rat_gene_id： 85252
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85252
Rat_swiss_prot_no： Q80U96
Rat_swiss_link： http://www.uniprot.org/uniprot/Q80U96
特異性： Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when acetylation at K568.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog
實(shí)測(cè)條帶： 125kD
功能： function:Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.,miscellaneous:Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the exportin family.,similarity:Contains 1 importin N-terminal domain.,similarity:Contains 10 HEAT repeats.,subcellular location:Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214 and RANBP3. Also found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
組織表達(dá)： Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.
科研貨號(hào)： PLN000058

CRM1 (Acetyl Lys568) Polyclonal Antibody

Catalog No PLN000058

Product information

基因名稱： XPO1
蛋白名稱： Exportin-1
Human_gene_id： 7514
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7514
Human_swiss_prot_no： O14980
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14980/entry
Mouse_gene_id： 103573
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103573
Mouse_swiss_prot_no： Q6P5F9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6P5F9
Rat_gene_id： 85252
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85252
Rat_swiss_prot_no： Q80U96
Rat_swiss_link： http://www.uniprot.org/uniprot/Q80U96
特異性： Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when acetylation at K568.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog
實(shí)測(cè)條帶： 125kD
功能： function:Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.,miscellaneous:Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the exportin family.,similarity:Contains 1 importin N-terminal domain.,similarity:Contains 10 HEAT repeats.,subcellular location:Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214 and RANBP3. Also found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
組織表達(dá)： Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.
科研貨號(hào)： PLN000058

Hunan UPT Biotechnology Co.,Ltd

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