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BMAL1 (Acetyl Lys538) Polyclonal Antibody

商品貨號(hào)： PLN000041

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： ARNTL
蛋白名稱： Aryl hydrocarbon receptor nuclear translocator-like protein 1
Human_gene_id： 406
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=406
Human_swiss_prot_no： O00327
Human_swiss_link： http://www.uniprot.org/uniprotkb/O00327/entry
Mouse_gene_id： 11865
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11865
Mouse_swiss_prot_no： Q9WTL8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WTL8
Rat_gene_id： 29657
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29657
Rat_swiss_prot_no： Q9EPW1
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9EPW1
特異性： Acetyl-BMAL1 (K538) Polyclonal Antibody detects endogenous levels of BMAL1 protein only when acetylated at K538.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ARNTL; BHLHE5; BMAL1; MOP3; PASD3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3
實(shí)測(cè)條帶： 70kD
信號(hào)通路： Circadian rhythm;
功能： alternative products:Additional isoforms seem to exist,function:ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,miscellaneous:CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and, disrupt circadian rhythmicity.,PTM:Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression.,PTM:Phosphorylated upon dimerization with CLOCK.,PTM:Sumoylated on Lys-259 upon dimerization with CLOCK.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.,tissue specificity:Highly expressed in the adult brain, skeletal muscle and heart.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .
組織表達(dá)： Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
科研貨號(hào)： PLN000041

BMAL1 (Acetyl Lys538) Polyclonal Antibody

Catalog No PLN000041

Product information

基因名稱： ARNTL
蛋白名稱： Aryl hydrocarbon receptor nuclear translocator-like protein 1
Human_gene_id： 406
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=406
Human_swiss_prot_no： O00327
Human_swiss_link： http://www.uniprot.org/uniprotkb/O00327/entry
Mouse_gene_id： 11865
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11865
Mouse_swiss_prot_no： Q9WTL8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WTL8
Rat_gene_id： 29657
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29657
Rat_swiss_prot_no： Q9EPW1
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9EPW1
特異性： Acetyl-BMAL1 (K538) Polyclonal Antibody detects endogenous levels of BMAL1 protein only when acetylated at K538.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ARNTL; BHLHE5; BMAL1; MOP3; PASD3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3
實(shí)測(cè)條帶： 70kD
信號(hào)通路： Circadian rhythm;
功能： alternative products:Additional isoforms seem to exist,function:ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,miscellaneous:CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and, disrupt circadian rhythmicity.,PTM:Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression.,PTM:Phosphorylated upon dimerization with CLOCK.,PTM:Sumoylated on Lys-259 upon dimerization with CLOCK.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.,tissue specificity:Highly expressed in the adult brain, skeletal muscle and heart.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .
組織表達(dá)： Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
科研貨號(hào)： PLN000041

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