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Histone H4 (Acetyl Lys12) Polyclonal Antibody

商品貨號： PLN000013

適應(yīng) 性： 人,小鼠,大鼠,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： HIST1H4A/HIST1H4B/HIST1H4C/HIST1H4D/HIST1H4E/HIST1H4F/HIST1H4H/HIST1H4I/HIST1H4J/HIST1H4K/HIST1H4L/HIST2H4A/HIST2H4B/HIST4H4
蛋白名稱： Histone H4
Human_gene_id： 121504/554313/8294/8359/8360/8361/8362/8363/8364/8365/8366/8367/8368/8370
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121504
Human_swiss_prot_no： P62805
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62805/entry
Mouse_gene_id： 1.00041e+008
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100041230
Mouse_swiss_prot_no： P62806
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62806
Rat_gene_id： 1.00361e+008
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100360950
Rat_swiss_prot_no： P62804
Rat_swiss_link： http://www.uniprot.org/uniprot/P62804
特異性： Acetyl-Histone H4 (K12) Polyclonal Antibody detects endogenous levels of Histone H4 protein only when acetylated at K12.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： HIST1H4A; H4/A; H4FA; HIST1H4B; H4/I; H4FI; HIST1H4C; H4/G; H4FG; HIST1H4D; H4/B; H4FB; HIST1H4E; H4/J; H4FJ; HIST1H4F; H4/C; H4FC; HIST1H4H; H4/H; H4FH; HIST1H4I; H4/M; H4FM; HIST1H4J; H4/E; H4FE; HIST1H4K; H4/D; H4FD; HIST1H4L; H4/K; H4FK;H4K12AC
實測條帶： 11kD
信號通路： Protein_Acetylation
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Acetylation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.,PTM:Citrullination at Arg-4 by PADI4 impairs methylation.,PTM:Monomethylated, dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.,PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.,PTM:Sumoylated, which is associated with transcriptional repression.,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.,similarity:Belongs to the histone H4 family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome.
組織表達(dá)： B-cell lymphoma,Bone marrow,Brain,Clones donated by HIP,Corpus call
tag： hot
科研貨號： PLN000013

Histone H4 (Acetyl Lys12) Polyclonal Antibody

Catalog No PLN000013

Product information

基因名稱： HIST1H4A/HIST1H4B/HIST1H4C/HIST1H4D/HIST1H4E/HIST1H4F/HIST1H4H/HIST1H4I/HIST1H4J/HIST1H4K/HIST1H4L/HIST2H4A/HIST2H4B/HIST4H4
蛋白名稱： Histone H4
Human_gene_id： 121504/554313/8294/8359/8360/8361/8362/8363/8364/8365/8366/8367/8368/8370
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121504
Human_swiss_prot_no： P62805
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62805/entry
Mouse_gene_id： 1.00041e+008
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100041230
Mouse_swiss_prot_no： P62806
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62806
Rat_gene_id： 1.00361e+008
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100360950
Rat_swiss_prot_no： P62804
Rat_swiss_link： http://www.uniprot.org/uniprot/P62804
特異性： Acetyl-Histone H4 (K12) Polyclonal Antibody detects endogenous levels of Histone H4 protein only when acetylated at K12.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： HIST1H4A; H4/A; H4FA; HIST1H4B; H4/I; H4FI; HIST1H4C; H4/G; H4FG; HIST1H4D; H4/B; H4FB; HIST1H4E; H4/J; H4FJ; HIST1H4F; H4/C; H4FC; HIST1H4H; H4/H; H4FH; HIST1H4I; H4/M; H4FM; HIST1H4J; H4/E; H4FE; HIST1H4K; H4/D; H4FD; HIST1H4L; H4/K; H4FK;H4K12AC
實測條帶： 11kD
信號通路： Protein_Acetylation
功能： function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Acetylation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.,PTM:Citrullination at Arg-4 by PADI4 impairs methylation.,PTM:Monomethylated, dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.,PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.,PTM:Sumoylated, which is associated with transcriptional repression.,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.,similarity:Belongs to the histone H4 family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome.
組織表達(dá)： B-cell lymphoma,Bone marrow,Brain,Clones donated by HIP,Corpus call
tag： hot
科研貨號： PLN000013

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