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SirT2 mouse mAb

商品貨號(hào)： PLA005219

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 7
基因名稱： sirt2
Human_gene_id： 22933
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22933
Human_swiss_prot_no： Q8IXJ6
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8IXJ6/entry
Mouse_swiss_prot_no： Q8VDQ8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8VDQ8
特異性： This antibody detects endogenous levels of SirT2 and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： wb 1:1000. IF 1:50-200
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： FLJ35621;FLJ37491;NAD dependent deacetylase sirtuin 2;NAD-dependent deacetylase sirtuin-2;NAD-dependent protein deacetylase sirtuin-2;Regulatory protein SIR2 homolog 2;Silencing information regulator 2 like;Silent information regulator 2;Silent mating type information regulation 2;Silent mating type information regulation 2 homolog;SIR 2;SIR2;SIR2 like;SIR2 like protein 2;Sir2 related protein type 2;SIR2, S. cerevisiae, homolog-loke 2;SIR2-like protein 2;SIR2L;SIR2L2;SIRT 2;SIRT2;SIRT2_HUMAN;Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae);Sirtuin 2;Sirtuin type 2;Sirtuin2.
實(shí)測(cè)條帶： 43kD
功能： catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.,enzyme regulation:Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide.,function:NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Phosphorylated at the G2/M transition of the cell cycle.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Colocalizes with microtubules.,subunit:Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton.,tissue specificity:Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.,
相關(guān)產(chǎn)品： YT4303,YM1271,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm, perinuclear region . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome . Perikaryon . Cell projection . Cell projection, growth cone . Myelin membrane . Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac) (PubMed:17726514, PubMed:23468428). Colocalizes with KMT5A at mitotic foci (PubMed:23468428). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody (PubMed:17488717). Colocalizes with microtubules (PubMed:12620231). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (PubMed:17726514). Colocalizes with EP300 in the nucleus (PubMed:24177535). Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells (PubMed:23908241). Deacetylates FOXO3 in the cytoplasm (By similarity). Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat (By similarity). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (By similarity). Colocalizes with alpha-tubulin in neuronal growth cone (By similarity). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (By similarity). Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (By similarity). Colocalizes with PARD3 in internodal region of axons (By similarity). Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasmic. .; [Isoform 2]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasmic. .; [Isoform 5]: Cytoplasm . Nucleus . Predominantly localized in the nucleus. .
組織表達(dá)： Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
科研貨號(hào)： PLA005219

SirT2 mouse mAb

Catalog No PLA005219

Product information

發(fā)貨日期： 7
基因名稱： sirt2
Human_gene_id： 22933
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22933
Human_swiss_prot_no： Q8IXJ6
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8IXJ6/entry
Mouse_swiss_prot_no： Q8VDQ8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8VDQ8
特異性： This antibody detects endogenous levels of SirT2 and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： wb 1:1000. IF 1:50-200
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： FLJ35621;FLJ37491;NAD dependent deacetylase sirtuin 2;NAD-dependent deacetylase sirtuin-2;NAD-dependent protein deacetylase sirtuin-2;Regulatory protein SIR2 homolog 2;Silencing information regulator 2 like;Silent information regulator 2;Silent mating type information regulation 2;Silent mating type information regulation 2 homolog;SIR 2;SIR2;SIR2 like;SIR2 like protein 2;Sir2 related protein type 2;SIR2, S. cerevisiae, homolog-loke 2;SIR2-like protein 2;SIR2L;SIR2L2;SIRT 2;SIRT2;SIRT2_HUMAN;Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae);Sirtuin 2;Sirtuin type 2;Sirtuin2.
實(shí)測(cè)條帶： 43kD
功能： catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.,enzyme regulation:Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide.,function:NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Phosphorylated at the G2/M transition of the cell cycle.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Colocalizes with microtubules.,subunit:Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton.,tissue specificity:Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.,
相關(guān)產(chǎn)品： YT4303,YM1271,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm, perinuclear region . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome . Perikaryon . Cell projection . Cell projection, growth cone . Myelin membrane . Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac) (PubMed:17726514, PubMed:23468428). Colocalizes with KMT5A at mitotic foci (PubMed:23468428). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody (PubMed:17488717). Colocalizes with microtubules (PubMed:12620231). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (PubMed:17726514). Colocalizes with EP300 in the nucleus (PubMed:24177535). Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells (PubMed:23908241). Deacetylates FOXO3 in the cytoplasm (By similarity). Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat (By similarity). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (By similarity). Colocalizes with alpha-tubulin in neuronal growth cone (By similarity). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (By similarity). Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (By similarity). Colocalizes with PARD3 in internodal region of axons (By similarity). Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasmic. .; [Isoform 2]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasmic. .; [Isoform 5]: Cytoplasm . Nucleus . Predominantly localized in the nucleus. .
組織表達(dá)： Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
科研貨號(hào)： PLA005219

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