其他名稱： ANOP3;cb236;Delta EF2a;lcc;MCOPS3;MGC148683;MGC2413;RGD1565646;Sex determining region Y box 2;SOX 2;Sox2;SOX2_HUMAN;SRY (sex determining region Y) box 2;SRY box containing gene 2;SRY related HMG box 2;SRY related HMG box gene 2;SRY-box 2;Transcription factor SOX 2;Transcription factor SOX-2;ysb.
實測條帶： 35kD
功能： disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain.,
相關產(chǎn)品： YM1221,YM1099,YM0594,YM0593
細胞定位： Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
其他名稱： ANOP3;cb236;Delta EF2a;lcc;MCOPS3;MGC148683;MGC2413;RGD1565646;Sex determining region Y box 2;SOX 2;Sox2;SOX2_HUMAN;SRY (sex determining region Y) box 2;SRY box containing gene 2;SRY related HMG box 2;SRY related HMG box gene 2;SRY-box 2;Transcription factor SOX 2;Transcription factor SOX-2;ysb.
實測條帶： 35kD
功能： disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain.,
相關產(chǎn)品： YM1221,YM1099,YM0594,YM0593
細胞定位： Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
組織表達： Fetal brain,Lung,Retina,
科研貨號： PLA005184
Hunan UPT Biotechnology Co.,Ltd
Website：m.hyjdss.com Servive hotline :4006916686
E-mail：service@uptbio.com
Address：
Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road,
Yuelu District, Changsha City, Hunan Province, China.
在線咨詢
湘公網(wǎng)安備