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JMJD6(N-term) mouse mAb

商品貨號： PLA005172

適應性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： jmjd6
Human_gene_id： 23210
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23210
Human_swiss_prot_no： Q6NYC1
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q6NYC1/entry
Mouse_swiss_prot_no： Q9ERI5
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9ERI5
特異性： This antibody detects endogenous levels of JMJD6(N-terminus) and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb 1:1000 icc 1:200
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Apoptotic cell clearance receptor;Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;Histone arginine demethylase JMJD6;JmjC domain-containing protein 6;JMJD 6;JMJD6;JMJD6_HUMAN;Jumonji domain containing 6;Jumonji domain-containing protein 6;KIAA0585;Lysyl-hydroxylase JMJD6;Peptide-lysine 5-dioxygenase JMJD6;Phosphatidylserine receptor;Protein PTDSR;PSR;PTDSR 1;PTDSR;PTDSR1.
實測條帶： 62kD
功能： caution:Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells. Phosphatidylserine receptor probably participates in apoptotic cell phagocytosis. This protein was identified using phage display expressing mAb 217, an antibody that specifically recognizes phosphatidylserine receptor. However, its nuclear localization and the fact that mAb 217 antibody still recognizes the phosphatidylserine receptor in mice lacking JMJD6, strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal.,domain:The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.,function:Arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me). Required for differentiation of multiple organs during embryogenesis. Probably acts as a key regulator of hematopoietic differentiation. Seems to be necessary for the regulation of macrophage cytokine responses.,induction:Up-regulated upon cytokine treatment, but not upon TNF-alpha treatment.,similarity:Belongs to the PTDSR family.,similarity:Contains 1 JmjC domain.,tissue specificity:Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus, nucleoplasm . Nucleus, nucleolus . Cytoplasm . Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. .
組織表達： Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
科研貨號： PLA005172

JMJD6(N-term) mouse mAb

Catalog No PLA005172

Product information

發(fā)貨日期： 7
基因名稱： jmjd6
Human_gene_id： 23210
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23210
Human_swiss_prot_no： Q6NYC1
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q6NYC1/entry
Mouse_swiss_prot_no： Q9ERI5
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9ERI5
特異性： This antibody detects endogenous levels of JMJD6(N-terminus) and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb 1:1000 icc 1:200
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Apoptotic cell clearance receptor;Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;Histone arginine demethylase JMJD6;JmjC domain-containing protein 6;JMJD 6;JMJD6;JMJD6_HUMAN;Jumonji domain containing 6;Jumonji domain-containing protein 6;KIAA0585;Lysyl-hydroxylase JMJD6;Peptide-lysine 5-dioxygenase JMJD6;Phosphatidylserine receptor;Protein PTDSR;PSR;PTDSR 1;PTDSR;PTDSR1.
實測條帶： 62kD
功能： caution:Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells. Phosphatidylserine receptor probably participates in apoptotic cell phagocytosis. This protein was identified using phage display expressing mAb 217, an antibody that specifically recognizes phosphatidylserine receptor. However, its nuclear localization and the fact that mAb 217 antibody still recognizes the phosphatidylserine receptor in mice lacking JMJD6, strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal.,domain:The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.,function:Arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me). Required for differentiation of multiple organs during embryogenesis. Probably acts as a key regulator of hematopoietic differentiation. Seems to be necessary for the regulation of macrophage cytokine responses.,induction:Up-regulated upon cytokine treatment, but not upon TNF-alpha treatment.,similarity:Belongs to the PTDSR family.,similarity:Contains 1 JmjC domain.,tissue specificity:Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus, nucleoplasm . Nucleus, nucleolus . Cytoplasm . Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. .
組織表達： Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
科研貨號： PLA005172

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

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