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UHRF1 Monoclonal Antibody

商品貨號： PLA005166

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： UHRF1
蛋白名稱： E3 ubiquitin-protein ligase UHRF1
Human_gene_id： 29128
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29128
Human_swiss_prot_no： Q96T88
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96T88/entry
Mouse_swiss_prot_no： Q8VDF2
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8VDF2
特異性： UHRF1 Monoclonal Antibody detects endogenous levels of UHRF1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquit
功能： developmental stage:Expressed in fetal thymus, liver and kidney.,domain:The RING finger is required for ubiquitin ligase activity.,domain:The YDG domain mediates the interaction with histone H3.,function:Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.,induction:Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a TP53/p53 and CDKN1A-dependent way. Induced by E2F1 transcription factor.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.,PTM:Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 1 YDG domain.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with histones H3, H1 and H2B (By similarity). Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Binds methylated CpG containing oligonucleotides.,tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.,
相關(guān)產(chǎn)品： YT5066,YM1202,YM1111,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
組織表達(dá)： Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
科研貨號： PLA005166

UHRF1 Monoclonal Antibody

Catalog No PLA005166

Product information

發(fā)貨日期： 7
基因名稱： UHRF1
蛋白名稱： E3 ubiquitin-protein ligase UHRF1
Human_gene_id： 29128
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29128
Human_swiss_prot_no： Q96T88
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96T88/entry
Mouse_swiss_prot_no： Q8VDF2
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8VDF2
特異性： UHRF1 Monoclonal Antibody detects endogenous levels of UHRF1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquit
功能： developmental stage:Expressed in fetal thymus, liver and kidney.,domain:The RING finger is required for ubiquitin ligase activity.,domain:The YDG domain mediates the interaction with histone H3.,function:Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.,induction:Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a TP53/p53 and CDKN1A-dependent way. Induced by E2F1 transcription factor.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.,PTM:Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 1 YDG domain.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with histones H3, H1 and H2B (By similarity). Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Binds methylated CpG containing oligonucleotides.,tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.,
相關(guān)產(chǎn)品： YT5066,YM1202,YM1111,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
組織表達(dá)： Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
科研貨號： PLA005166

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

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Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.