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PRMT6 Monoclonal Antibody

商品貨號： PLA005144

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： PRMT6
蛋白名稱： Protein arginine N-methyltransferase 6
Human_gene_id： 55170
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55170
Human_swiss_prot_no： Q96LA8
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96LA8/entry
Mouse_gene_id： 99890
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=99890
Mouse_swiss_prot_no： Q6NZB1
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6NZB1
特異性： PRMT6 Monoclonal Antibody detects endogenous levels of PRMT6 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PRMT6; HRMT1L6; Protein arginine N-methyltransferase 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6
功能： catalytic activity:S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.,function:Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).,PTM:Automethylated.,similarity:Belongs to the protein arginine N-methyltransferase family. PRMT6 subfamily.,subunit:Interacts with (and methylates) HIV-1 Tat, Rev and Nucleocapsid protein p7 (NC).,tissue specificity:Highly expressed in kidney and testes.,
相關(guān)產(chǎn)品： YM1223,YM1086,YM0536,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus .
組織表達： Highly expressed in kidney and testis.
科研貨號： PLA005144

PRMT6 Monoclonal Antibody

Catalog No PLA005144

Product information

發(fā)貨日期： 7
基因名稱： PRMT6
蛋白名稱： Protein arginine N-methyltransferase 6
Human_gene_id： 55170
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55170
Human_swiss_prot_no： Q96LA8
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96LA8/entry
Mouse_gene_id： 99890
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=99890
Mouse_swiss_prot_no： Q6NZB1
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6NZB1
特異性： PRMT6 Monoclonal Antibody detects endogenous levels of PRMT6 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PRMT6; HRMT1L6; Protein arginine N-methyltransferase 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6
功能： catalytic activity:S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.,function:Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).,PTM:Automethylated.,similarity:Belongs to the protein arginine N-methyltransferase family. PRMT6 subfamily.,subunit:Interacts with (and methylates) HIV-1 Tat, Rev and Nucleocapsid protein p7 (NC).,tissue specificity:Highly expressed in kidney and testes.,
相關(guān)產(chǎn)品： YM1223,YM1086,YM0536,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus .
組織表達： Highly expressed in kidney and testis.
科研貨號： PLA005144

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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