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PPX Monoclonal Antibody

商品貨號： PLA005142

適應(yīng) 性： 人,小鼠,大鼠,牛,狗,斑馬魚

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： PPP4C
蛋白名稱： Serine/threonine-protein phosphatase 4 catalytic subunit
Human_gene_id： 5531
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5531
Human_swiss_prot_no： P60510
Human_swiss_link： http://www.uniprot.org/uniprotkb/P60510/entry
Mouse_gene_id： 56420
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56420
Mouse_swiss_prot_no： P97470
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97470
Rat_gene_id： 171366
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171366
Rat_swiss_prot_no： Q5BJ92
Rat_swiss_link： http://www.uniprot.org/uniprot/Q5BJ92
特異性： PPX Monoclonal Antibody detects endogenous levels of PPX protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PPP4C; PPP4; PPX; Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Pp4; Protein phosphatase X; PP-X
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,function:Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.,subunit:Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.,
相關(guān)產(chǎn)品： YM1227,YM1083,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
組織表達(dá)： Placenta,
科研貨號： PLA005142

PPX Monoclonal Antibody

Catalog No PLA005142

Product information

發(fā)貨日期： 7
基因名稱： PPP4C
蛋白名稱： Serine/threonine-protein phosphatase 4 catalytic subunit
Human_gene_id： 5531
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5531
Human_swiss_prot_no： P60510
Human_swiss_link： http://www.uniprot.org/uniprotkb/P60510/entry
Mouse_gene_id： 56420
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56420
Mouse_swiss_prot_no： P97470
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97470
Rat_gene_id： 171366
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171366
Rat_swiss_prot_no： Q5BJ92
Rat_swiss_link： http://www.uniprot.org/uniprot/Q5BJ92
特異性： PPX Monoclonal Antibody detects endogenous levels of PPX protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PPP4C; PPP4; PPX; Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Pp4; Protein phosphatase X; PP-X
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,function:Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.,subunit:Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.,
相關(guān)產(chǎn)品： YM1227,YM1083,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
組織表達(dá)： Placenta,
科研貨號： PLA005142

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