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NSD1 Monoclonal Antibody

商品貨號(hào)： PLA005128

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱： NSD1
蛋白名稱： Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific
Human_gene_id： 64324
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64324
Human_swiss_prot_no： Q96L73
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96L73/entry
Mouse_swiss_prot_no： O88491
Mouse_swiss_link： http://www.uniprot.org/uniprot/O88491
特異性： NSD1 Monoclonal Antibody detects endogenous levels of NSD1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： NSD1; ARA267; KMT3B; Histone-lysine N-methyltransferase; H3 lysine-36 and H4 lysine-20 specific; Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; H3-K36-HMTase; H4-K20-HMTase; Lysine N-methyltr
信號(hào)通路： Lysine degradation;
功能： catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product.,disease:A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98.,disease:Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in NSD1 are the cause of Sotos syndrome [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.,disease:Defects in NSD1 are the cause of Weaver syndrome (WES) [MIM:277590]. WES is a syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly.,function:Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro) (By similarity). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 AWS domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 2 PWWP domains.,similarity:Contains 4 PHD-type zinc fingers.,subunit:Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand (By similarity). Interacts with AR DNA-and ligand-binding domains.,tissue specificity:Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome .
組織表達(dá)： Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.
科研貨號(hào)： PLA005128

NSD1 Monoclonal Antibody

Catalog No PLA005128

Product information

發(fā)貨日期： 7
基因名稱： NSD1
蛋白名稱： Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific
Human_gene_id： 64324
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64324
Human_swiss_prot_no： Q96L73
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q96L73/entry
Mouse_swiss_prot_no： O88491
Mouse_swiss_link： http://www.uniprot.org/uniprot/O88491
特異性： NSD1 Monoclonal Antibody detects endogenous levels of NSD1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： NSD1; ARA267; KMT3B; Histone-lysine N-methyltransferase; H3 lysine-36 and H4 lysine-20 specific; Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; H3-K36-HMTase; H4-K20-HMTase; Lysine N-methyltr
信號(hào)通路： Lysine degradation;
功能： catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product.,disease:A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98.,disease:Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in NSD1 are the cause of Sotos syndrome [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.,disease:Defects in NSD1 are the cause of Weaver syndrome (WES) [MIM:277590]. WES is a syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly.,function:Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro) (By similarity). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 AWS domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 2 PWWP domains.,similarity:Contains 4 PHD-type zinc fingers.,subunit:Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand (By similarity). Interacts with AR DNA-and ligand-binding domains.,tissue specificity:Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome .
組織表達(dá)： Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.
科研貨號(hào)： PLA005128

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