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HAUSP Monoclonal Antibody

商品貨號： PLA005109

適應(yīng) 性： 人,小鼠,大鼠,狗,豬

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： USP7
蛋白名稱： Ubiquitin carboxyl-terminal hydrolase 7
Human_gene_id： 7874
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7874
Human_swiss_prot_no： Q93009
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q93009/entry
Mouse_gene_id： 252870
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=252870
Mouse_swiss_prot_no： Q6A4J8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6A4J8
Rat_gene_id： 360471
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360471
Rat_swiss_prot_no： Q4VSI4
Rat_swiss_link： http://www.uniprot.org/uniprot/Q4VSI4
特異性： HAUSP Monoclonal Antibody detects endogenous levels of HAUSP protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： USP7; HAUSP; Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
功能： catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,enzyme regulation:Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl but is inhibited at concentrations of 195 mM and higher.,function:Cleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis.,PTM:Polyneddylated.,PTM:Polyubiquitinated.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MATH domain.,subcellular location:Present in a minority of ND10 nuclear bodies. Association with VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus.,subunit:Monomer. Interacts with TP53, MDM2 and UBXN6. Interacts with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 and Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than TP53 and can compete with it for USP7 binding. Binding to VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions.,tissue specificity:Widely expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
組織表達(dá)： Expressed in neural progenitor cells (at protein level) (PubMed:21258371). Widely expressed. Overexpressed in prostate cancer.
tag： hot
科研貨號： PLA005109

HAUSP Monoclonal Antibody

Catalog No PLA005109

Product information

發(fā)貨日期： 7
基因名稱： USP7
蛋白名稱： Ubiquitin carboxyl-terminal hydrolase 7
Human_gene_id： 7874
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7874
Human_swiss_prot_no： Q93009
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q93009/entry
Mouse_gene_id： 252870
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=252870
Mouse_swiss_prot_no： Q6A4J8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6A4J8
Rat_gene_id： 360471
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360471
Rat_swiss_prot_no： Q4VSI4
Rat_swiss_link： http://www.uniprot.org/uniprot/Q4VSI4
特異性： HAUSP Monoclonal Antibody detects endogenous levels of HAUSP protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： USP7; HAUSP; Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
功能： catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,enzyme regulation:Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl but is inhibited at concentrations of 195 mM and higher.,function:Cleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis.,PTM:Polyneddylated.,PTM:Polyubiquitinated.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MATH domain.,subcellular location:Present in a minority of ND10 nuclear bodies. Association with VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus.,subunit:Monomer. Interacts with TP53, MDM2 and UBXN6. Interacts with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 and Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than TP53 and can compete with it for USP7 binding. Binding to VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions.,tissue specificity:Widely expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
組織表達(dá)： Expressed in neural progenitor cells (at protein level) (PubMed:21258371). Widely expressed. Overexpressed in prostate cancer.
tag： hot
科研貨號： PLA005109

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