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Crk II Monoclonal Antibody

商品貨號： PLA005099

適應(yīng) 性： 人,小鼠,狗,兔

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： CRK
蛋白名稱： Adapter molecule crk
Human_gene_id： 1398
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1398
Human_swiss_prot_no： P46108
Human_swiss_link： http://www.uniprot.org/uniprotkb/P46108/entry
Mouse_gene_id： 12928
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12928
Mouse_swiss_prot_no： Q64010
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q64010
Rat_swiss_prot_no： Q63768
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941Q63768
特異性： Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
信號通路： MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Chemokine;Focal adhesion;Fc gamma R-mediated phagocytosis;Neurotrophin;Regulates Actin and Cytoskeleton;Insulin_Receptor;Pathways in cancer;Renal cell carcinoma;Chronic myeloid leukemia;
功能： domain:The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.,domain:The SH2 domain mediates interaction with SHB.,function:The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4.,PTM:Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.,PTM:Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH3 domains.,subcellular location:Translocated to the plasma membrane upon cell adhesion.,subunit:Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK3 via its first SH3 domain. Interacts with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as EGFR, PDGFR and INSR via its SH2 domain (By similarity). Interacts with DOCK1 and DOCK4. Interacts with SHB.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .
組織表達： Embryonic lung,Epithelium,Eye,Lung,Placenta,
科研貨號： PLA005099

Crk II Monoclonal Antibody

Catalog No PLA005099

Product information

發(fā)貨日期： 7
基因名稱： CRK
蛋白名稱： Adapter molecule crk
Human_gene_id： 1398
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1398
Human_swiss_prot_no： P46108
Human_swiss_link： http://www.uniprot.org/uniprotkb/P46108/entry
Mouse_gene_id： 12928
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12928
Mouse_swiss_prot_no： Q64010
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q64010
Rat_swiss_prot_no： Q63768
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941Q63768
特異性： Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
信號通路： MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Chemokine;Focal adhesion;Fc gamma R-mediated phagocytosis;Neurotrophin;Regulates Actin and Cytoskeleton;Insulin_Receptor;Pathways in cancer;Renal cell carcinoma;Chronic myeloid leukemia;
功能： domain:The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.,domain:The SH2 domain mediates interaction with SHB.,function:The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4.,PTM:Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.,PTM:Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH3 domains.,subcellular location:Translocated to the plasma membrane upon cell adhesion.,subunit:Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK3 via its first SH3 domain. Interacts with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as EGFR, PDGFR and INSR via its SH2 domain (By similarity). Interacts with DOCK1 and DOCK4. Interacts with SHB.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .
組織表達： Embryonic lung,Epithelium,Eye,Lung,Placenta,
科研貨號： PLA005099

Hunan UPT Biotechnology Co.,Ltd

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