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CaMKIV Monoclonal Antibody

商品貨號(hào)： PLA005096

適應(yīng) 性： 人,小鼠,大鼠,雞,狗,豬

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱： CAMK4
蛋白名稱： Calcium/calmodulin-dependent protein kinase type IV
Human_gene_id： 814
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=814
Human_swiss_prot_no： Q16566
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q16566/entry
Mouse_swiss_prot_no： P08414
Mouse_swiss_link： http://www.uniprot.org/uniprot/P08414
Rat_gene_id： 25050
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25050
Rat_swiss_prot_no： P13234
Rat_swiss_link： http://www.uniprot.org/uniprot/P13234
特異性： CaMKIV Monoclonal Antibody detects endogenous levels of CaMKIV protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： CAMK4; CAMK; CAMK-GR; CAMKIV; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CaM kinase-GR
信號(hào)通路： Calcium;Long-term potentiation;Neurotrophin;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.,PTM:Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.,subunit:Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.,tissue specificity:Expressed in epithelial ovarian cancer tissue.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .
組織表達(dá)： Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
tag： hot
科研貨號(hào)： PLA005096

CaMKIV Monoclonal Antibody

Catalog No PLA005096

Product information

發(fā)貨日期： 7
基因名稱： CAMK4
蛋白名稱： Calcium/calmodulin-dependent protein kinase type IV
Human_gene_id： 814
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=814
Human_swiss_prot_no： Q16566
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q16566/entry
Mouse_swiss_prot_no： P08414
Mouse_swiss_link： http://www.uniprot.org/uniprot/P08414
Rat_gene_id： 25050
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25050
Rat_swiss_prot_no： P13234
Rat_swiss_link： http://www.uniprot.org/uniprot/P13234
特異性： CaMKIV Monoclonal Antibody detects endogenous levels of CaMKIV protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： CAMK4; CAMK; CAMK-GR; CAMKIV; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CaM kinase-GR
信號(hào)通路： Calcium;Long-term potentiation;Neurotrophin;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.,PTM:Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.,subunit:Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.,tissue specificity:Expressed in epithelial ovarian cancer tissue.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .
組織表達(dá)： Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
tag： hot
科研貨號(hào)： PLA005096

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