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BACE Monoclonal Antibody

商品貨號(hào)： PLA005095

適應(yīng) 性： 人,大鼠,牛,狗,豬

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 7
基因名稱： BACE1
蛋白名稱： Beta-secretase 1
Human_gene_id： 23621
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23621
Human_swiss_prot_no： P56817
Human_swiss_link： http://www.uniprot.org/uniprotkb/P56817/entry
Mouse_swiss_prot_no： P56818
Mouse_swiss_link： http://www.uniprot.org/uniprot/P56818
Rat_gene_id： 29392
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29392
Rat_swiss_prot_no： P56819
Rat_swiss_link： http://www.uniprot.org/uniprot/P56819
特異性： BACE Monoclonal Antibody detects endogenous levels of BACE protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
信號(hào)通路： Alzheimer's disease;
功能： catalytic activity:Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.,enzyme regulation:Inhibited by RTN3 and RTN4.,function:Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.,similarity:Belongs to the peptidase A1 family.,subunit:Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.,tissue specificity:Brain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cell membrane ; Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection, axon . Cell projection, dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016). .
組織表達(dá)： Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
科研貨號(hào)： PLA005095

BACE Monoclonal Antibody

Catalog No PLA005095

Product information

發(fā)貨日期： 7
基因名稱： BACE1
蛋白名稱： Beta-secretase 1
Human_gene_id： 23621
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23621
Human_swiss_prot_no： P56817
Human_swiss_link： http://www.uniprot.org/uniprotkb/P56817/entry
Mouse_swiss_prot_no： P56818
Mouse_swiss_link： http://www.uniprot.org/uniprot/P56818
Rat_gene_id： 29392
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29392
Rat_swiss_prot_no： P56819
Rat_swiss_link： http://www.uniprot.org/uniprot/P56819
特異性： BACE Monoclonal Antibody detects endogenous levels of BACE protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
信號(hào)通路： Alzheimer's disease;
功能： catalytic activity:Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.,enzyme regulation:Inhibited by RTN3 and RTN4.,function:Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.,similarity:Belongs to the peptidase A1 family.,subunit:Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.,tissue specificity:Brain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cell membrane ; Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection, axon . Cell projection, dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016). .
組織表達(dá)： Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
科研貨號(hào)： PLA005095

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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