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ACE1 Monoclonal Antibody

商品貨號(hào)： PLA005085

適應(yīng) 性： 人,小鼠,大鼠,牛

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： ACE
蛋白名稱： Angiotensin-converting enzyme
Human_gene_id： 1636
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1636
Human_swiss_prot_no： P12821
Human_swiss_link： http://www.uniprot.org/uniprotkb/P12821/entry
Mouse_gene_id： 11421
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11421
Mouse_swiss_prot_no： P09470
Mouse_swiss_link： http://www.uniprot.org/uniprot/P09470
Rat_gene_id： 24310
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24310
Rat_swiss_prot_no： P47820
Rat_swiss_link： http://www.uniprot.org/uniprot/P47820
特異性： ACE1 Monoclonal Antibody detects endogenous levels of ACE1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ACE; DCP; DCP1; Angiotensin-converting enzyme; ACE; Dipeptidyl carboxypeptidase I; Kininase II; CD antigen CD143
信號(hào)通路： Renin-angiotensin system;Hypertrophic cardiomyopathy (HCM);
功能： catalytic activity:Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.,cofactor:Binds 2 zinc ions per subunit. The Testis-specific isoform only binds 1 zinc ion per subunit.,cofactor:Binds 3 chloride ions per subunit.,disease:Defects in ACE are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).,disease:Genetic variations in ACE could influence susceptibility to diabetic nephropathy [MIM:612624]; also called susceptibility to microvascular complications of diabetes type 3 (MVCD3) or susceptibility to diabetic end-stage renal disease (ESRD). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,disease:Genetic variations in ACE may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,enzyme regulation:Strongly activated by chloride. Specifically inhibited by lisinopril, captopril and enalaprilat.,function:Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.,induction:Up-regulated in failing heart.,miscellaneous:Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction.,miscellaneous:The glycosidase activity probably uses different active site residues than the metalloprotease activity.,online information:The Singapore human mutation and polymorphism database,PTM:Phosphorylated by CK2 on Ser-1299; which allows membrane retention.,similarity:Belongs to the peptidase M2 family.,tissue specificity:Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. The testis-specific isoforn is expressed in spermatocytes, adult testis.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： [Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm . Detected in both cell membrane and cytoplasm in neurons. .
組織表達(dá)： Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
tag： hot
科研貨號(hào)： PLA005085

ACE1 Monoclonal Antibody

Catalog No PLA005085

Product information

發(fā)貨日期： 7
基因名稱： ACE
蛋白名稱： Angiotensin-converting enzyme
Human_gene_id： 1636
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1636
Human_swiss_prot_no： P12821
Human_swiss_link： http://www.uniprot.org/uniprotkb/P12821/entry
Mouse_gene_id： 11421
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11421
Mouse_swiss_prot_no： P09470
Mouse_swiss_link： http://www.uniprot.org/uniprot/P09470
Rat_gene_id： 24310
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24310
Rat_swiss_prot_no： P47820
Rat_swiss_link： http://www.uniprot.org/uniprot/P47820
特異性： ACE1 Monoclonal Antibody detects endogenous levels of ACE1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ACE; DCP; DCP1; Angiotensin-converting enzyme; ACE; Dipeptidyl carboxypeptidase I; Kininase II; CD antigen CD143
信號(hào)通路： Renin-angiotensin system;Hypertrophic cardiomyopathy (HCM);
功能： catalytic activity:Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.,cofactor:Binds 2 zinc ions per subunit. The Testis-specific isoform only binds 1 zinc ion per subunit.,cofactor:Binds 3 chloride ions per subunit.,disease:Defects in ACE are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).,disease:Genetic variations in ACE could influence susceptibility to diabetic nephropathy [MIM:612624]; also called susceptibility to microvascular complications of diabetes type 3 (MVCD3) or susceptibility to diabetic end-stage renal disease (ESRD). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,disease:Genetic variations in ACE may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,enzyme regulation:Strongly activated by chloride. Specifically inhibited by lisinopril, captopril and enalaprilat.,function:Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.,induction:Up-regulated in failing heart.,miscellaneous:Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction.,miscellaneous:The glycosidase activity probably uses different active site residues than the metalloprotease activity.,online information:The Singapore human mutation and polymorphism database,PTM:Phosphorylated by CK2 on Ser-1299; which allows membrane retention.,similarity:Belongs to the peptidase M2 family.,tissue specificity:Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. The testis-specific isoforn is expressed in spermatocytes, adult testis.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： [Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm . Detected in both cell membrane and cytoplasm in neurons. .
組織表達(dá)： Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
tag： hot
科研貨號(hào)： PLA005085

Hunan UPT Biotechnology Co.,Ltd

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