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Wnt-5a Monoclonal Antibody

商品貨號(hào)： PLA005083

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： WNT5A
蛋白名稱： Protein Wnt-5a
Human_gene_id： 7474
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7474
Human_swiss_prot_no： P41221
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41221/entry
Mouse_swiss_prot_no： P22725
Mouse_swiss_link： http://www.uniprot.org/uniprot/P22725
特異性： Wnt-5a Monoclonal Antibody detects endogenous levels of Wnt-5a protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： WNT5A; Protein Wnt-5a
信號(hào)通路： WNT;WNT-T CELLHedgehog;Melanogenesis;Pathways in cancer;Basal cell carcinoma;
功能： function:Ligand for members of the frizzled family of seven transmembrane receptors.,function:Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.,PTM:Glycosylation is necessary for secretion but not for activity.,PTM:Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN.,tissue specificity:Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).,
相關(guān)產(chǎn)品： YM0652,YM0651,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Secreted, extracellular space, extracellular matrix . Secreted .
組織表達(dá)： Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level) (PubMed:15735754). Detected in neonate heart and lung (PubMed:8288227).
科研貨號(hào)： PLA005083

Wnt-5a Monoclonal Antibody

Catalog No PLA005083

Product information

發(fā)貨日期： 7
基因名稱： WNT5A
蛋白名稱： Protein Wnt-5a
Human_gene_id： 7474
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7474
Human_swiss_prot_no： P41221
Human_swiss_link： http://www.uniprot.org/uniprotkb/P41221/entry
Mouse_swiss_prot_no： P22725
Mouse_swiss_link： http://www.uniprot.org/uniprot/P22725
特異性： Wnt-5a Monoclonal Antibody detects endogenous levels of Wnt-5a protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： WNT5A; Protein Wnt-5a
信號(hào)通路： WNT;WNT-T CELLHedgehog;Melanogenesis;Pathways in cancer;Basal cell carcinoma;
功能： function:Ligand for members of the frizzled family of seven transmembrane receptors.,function:Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.,PTM:Glycosylation is necessary for secretion but not for activity.,PTM:Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN.,tissue specificity:Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).,
相關(guān)產(chǎn)品： YM0652,YM0651,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Secreted, extracellular space, extracellular matrix . Secreted .
組織表達(dá)： Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level) (PubMed:15735754). Detected in neonate heart and lung (PubMed:8288227).
科研貨號(hào)： PLA005083

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