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TRIM5α Monoclonal Antibody

商品貨號(hào)： PLA005067

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

在線(xiàn)咨詢(xún)

MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱(chēng)： TRIM5
蛋白名稱(chēng)： Tripartite motif-containing protein 5
Human_gene_id： 85363
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85363
Human_swiss_prot_no： Q9C035
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9C035/entry
特異性： TRIM5α Monoclonal Antibody detects endogenous levels of TRIM5α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋?zhuān)? WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： TRIM5; RNF88; Tripartite motif-containing protein 5; RING finger protein 88
功能： domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Cytoplasmic bodies.,subunit:Isoform Alpha forms homotrimers, and may interact with retroviral CA protein. Isoform Delta interacts with BTBD1 and BTBD2.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity). .
組織表達(dá)： Brain,Placenta,Rhabdomyosarcoma,
科研貨號(hào)： PLA005067

TRIM5α Monoclonal Antibody

Catalog No PLA005067

Product information

發(fā)貨日期： 7
基因名稱(chēng)： TRIM5
蛋白名稱(chēng)： Tripartite motif-containing protein 5
Human_gene_id： 85363
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85363
Human_swiss_prot_no： Q9C035
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9C035/entry
特異性： TRIM5α Monoclonal Antibody detects endogenous levels of TRIM5α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋?zhuān)? WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： TRIM5; RNF88; Tripartite motif-containing protein 5; RING finger protein 88
功能： domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Cytoplasmic bodies.,subunit:Isoform Alpha forms homotrimers, and may interact with retroviral CA protein. Isoform Delta interacts with BTBD1 and BTBD2.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity). .
組織表達(dá)： Brain,Placenta,Rhabdomyosarcoma,
科研貨號(hào)： PLA005067

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