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TBL1X Monoclonal Antibody

商品貨號： PLA005054

適應(yīng) 性： 人,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： TBL1X
蛋白名稱： F-box-like/WD repeat-containing protein TBL1X
Human_gene_id： 6907
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6907
Human_swiss_prot_no： O60907
Human_swiss_link： http://www.uniprot.org/uniprotkb/O60907/entry
Mouse_swiss_prot_no： Q9QXE7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QXE7
特異性： TBL1X Monoclonal Antibody detects endogenous levels of TBL1X protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： TBL1X; TBL1; F-box-like/WD repeat-containing protein TBL1X; SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1; X-linked
信號通路： WNT;WNT-T CELL
功能： disease:Defects in TBL1X may be involved in the pathogenesis of ocular albinism with late-onset sensorineural deafness (OASD). OASD is an X-linked disorder characterized by ocular albinism and progressive sensineural hearing loss in the fourth and fifth decades of life. OASD may be caused by deletion of both GPR143/OA1 and TBL1X adjacent genes; TBL1X defects possibly causing the hearing phenotype.,domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： YM1208,YM0610,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Colocalized with MECP2 to the heterochromatin foci. .
組織表達(dá)： Ubiquitous.
科研貨號： PLA005054

TBL1X Monoclonal Antibody

Catalog No PLA005054

Product information

發(fā)貨日期： 7
基因名稱： TBL1X
蛋白名稱： F-box-like/WD repeat-containing protein TBL1X
Human_gene_id： 6907
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6907
Human_swiss_prot_no： O60907
Human_swiss_link： http://www.uniprot.org/uniprotkb/O60907/entry
Mouse_swiss_prot_no： Q9QXE7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QXE7
特異性： TBL1X Monoclonal Antibody detects endogenous levels of TBL1X protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： TBL1X; TBL1; F-box-like/WD repeat-containing protein TBL1X; SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1; X-linked
信號通路： WNT;WNT-T CELL
功能： disease:Defects in TBL1X may be involved in the pathogenesis of ocular albinism with late-onset sensorineural deafness (OASD). OASD is an X-linked disorder characterized by ocular albinism and progressive sensineural hearing loss in the fourth and fifth decades of life. OASD may be caused by deletion of both GPR143/OA1 and TBL1X adjacent genes; TBL1X defects possibly causing the hearing phenotype.,domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： YM1208,YM0610,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Colocalized with MECP2 to the heterochromatin foci. .
組織表達(dá)： Ubiquitous.
科研貨號： PLA005054

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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