其他名稱： TAB2; KIAA0733; MAP3K7IP2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2
功能： function:Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway.,PTM:Phosphorylated.,PTM:Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.,similarity:Contains 1 CUE domain.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Following IL1 stimulation, translocation occurs from the membrane to cytosol.,subunit:Interacts with MAP3K7 and TRAF6. Interacts with NCOR1 and HDAC3 to form a ternary complex.,tissue specificity:Widely expressed.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). .
組織表達： Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
科研貨號： PLA005053
TAB2 Monoclonal Antibody
Catalog NoPLA005053
Product information
發(fā)貨日期： 7
基因名稱： TAB2
蛋白名稱： TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
其他名稱： TAB2; KIAA0733; MAP3K7IP2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2
功能： function:Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway.,PTM:Phosphorylated.,PTM:Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.,similarity:Contains 1 CUE domain.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Following IL1 stimulation, translocation occurs from the membrane to cytosol.,subunit:Interacts with MAP3K7 and TRAF6. Interacts with NCOR1 and HDAC3 to form a ternary complex.,tissue specificity:Widely expressed.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). .
組織表達： Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
科研貨號： PLA005053
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