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SOD-1 Monoclonal Antibody

商品貨號： PLA005042

適應(yīng) 性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： SOD1
蛋白名稱： Superoxide dismutase [Cu-Zn]
Human_gene_id： 6647
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6647
Human_swiss_prot_no： P00441
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00441/entry
Mouse_gene_id： 20655
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20655
Mouse_swiss_prot_no： P08228
Mouse_swiss_link： http://www.uniprot.org/uniprot/P08228
特異性： SOD-1 Monoclonal Antibody detects endogenous levels of SOD-1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
信號通路： Amyotrophic lateral sclerosis (ALS);Huntington's disease;Prion diseases;
功能： catalytic activity:2 superoxide + 2 H(+) = O(2) + H(2)O(2).,cofactor:Binds 1 copper ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.,function:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.,miscellaneous:The protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form.,online information:ALS genetic mutations db,online information:Superoxide dismutase entry,PTM:Unlike wild-type protein, the pathogenics variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A; which leads to their proteasomal degradation.,similarity:Belongs to the Cu-Zn superoxide dismutase family.,subunit:Homodimer. The pathogenics variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not.,
相關(guān)產(chǎn)品： YT4364,YM3406,YM0590,YD0094
細胞定位： Cytoplasm . Mitochondrion . Nucleus . Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. .
組織表達： Colon,Fetal brain cortex,Placenta,
科研貨號： PLA005042

SOD-1 Monoclonal Antibody

Catalog No PLA005042

Product information

發(fā)貨日期： 7
基因名稱： SOD1
蛋白名稱： Superoxide dismutase [Cu-Zn]
Human_gene_id： 6647
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6647
Human_swiss_prot_no： P00441
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00441/entry
Mouse_gene_id： 20655
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20655
Mouse_swiss_prot_no： P08228
Mouse_swiss_link： http://www.uniprot.org/uniprot/P08228
特異性： SOD-1 Monoclonal Antibody detects endogenous levels of SOD-1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
信號通路： Amyotrophic lateral sclerosis (ALS);Huntington's disease;Prion diseases;
功能： catalytic activity:2 superoxide + 2 H(+) = O(2) + H(2)O(2).,cofactor:Binds 1 copper ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.,function:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.,miscellaneous:The protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form.,online information:ALS genetic mutations db,online information:Superoxide dismutase entry,PTM:Unlike wild-type protein, the pathogenics variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A; which leads to their proteasomal degradation.,similarity:Belongs to the Cu-Zn superoxide dismutase family.,subunit:Homodimer. The pathogenics variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not.,
相關(guān)產(chǎn)品： YT4364,YM3406,YM0590,YD0094
細胞定位： Cytoplasm . Mitochondrion . Nucleus . Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. .
組織表達： Colon,Fetal brain cortex,Placenta,
科研貨號： PLA005042

Hunan UPT Biotechnology Co.,Ltd

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