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Skp2 p45 Monoclonal Antibody

商品貨號： PLA005035

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： SKP2
蛋白名稱： S-phase kinase-associated protein 2
Human_gene_id： 6502
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6502
Human_swiss_prot_no： Q13309
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13309/entry
Mouse_swiss_prot_no： Q9Z0Z3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z0Z3
特異性： Skp2 p45 Monoclonal Antibody detects endogenous levels of Skp2 p45 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2
信號通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Ubiquitin mediated proteolysis;Pathways in cancer;Small cell lung cancer;
功能： function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of the SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin A-CDK2 complex. Interacts with ORC1L, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 and MLL.,
相關(guān)產(chǎn)品： YT4311,YM0579,KA3378C,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus .
組織表達(dá)： Epithelium,Liver,Placenta,Prostatic carcinoma,
科研貨號： PLA005035

Skp2 p45 Monoclonal Antibody

Catalog No PLA005035

Product information

發(fā)貨日期： 7
基因名稱： SKP2
蛋白名稱： S-phase kinase-associated protein 2
Human_gene_id： 6502
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6502
Human_swiss_prot_no： Q13309
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13309/entry
Mouse_swiss_prot_no： Q9Z0Z3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z0Z3
特異性： Skp2 p45 Monoclonal Antibody detects endogenous levels of Skp2 p45 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2
信號通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Ubiquitin mediated proteolysis;Pathways in cancer;Small cell lung cancer;
功能： function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of the SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin A-CDK2 complex. Interacts with ORC1L, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 and MLL.,
相關(guān)產(chǎn)品： YT4311,YM0579,KA3378C,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus .
組織表達(dá)： Epithelium,Liver,Placenta,Prostatic carcinoma,
科研貨號： PLA005035

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.