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PTH/PTHrP-R Monoclonal Antibody

商品貨號(hào)： PLA005004

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 7
基因名稱： PTH1R
蛋白名稱： Parathyroid hormone/parathyroid hormone-related peptide receptor
Human_gene_id： 5745
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5745
Human_swiss_prot_no： Q03431
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q03431/entry
Mouse_swiss_prot_no： P41593
Mouse_swiss_link： http://www.uniprot.org/uniprot/P41593
特異性： PTH/PTHrP-R Monoclonal Antibody detects endogenous levels of PTH/PTHrP-R protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor
信號(hào)通路： Neuroactive ligand-receptor interaction;
功能： disease:Defects in PTH1R are a cause of primary failure of tooth eruption (PFE) [MIM:125350]. PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.,disease:Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD) [MIM:215045]. BOCD is a severe skeletal dysplasia.,disease:Defects in PTH1R are the cause of Eiken syndrome [MIM:600002]; also called Eiken skeletal dysplasia or bone modeling defect of hands and feet. Eiken syndrome is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.,disease:Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC) [MIM:156400]. JMC is a rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.,disease:Defects in PTH1R may be a cause of enchondromatosis [MIM:166000]. Enchondromas are common benign cartilage tumors of bone. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.,function:This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Expressed in most tissues. Most abundant in kidney, bone and liver.,
相關(guān)產(chǎn)品： YT5856,YT3898,YM0542,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cell membrane ; Multi-pass membrane protein .
組織表達(dá)： Expressed in most tissues. Most abundant in kidney, bone and liver.
科研貨號(hào)： PLA005004

PTH/PTHrP-R Monoclonal Antibody

Catalog No PLA005004

Product information

發(fā)貨日期： 7
基因名稱： PTH1R
蛋白名稱： Parathyroid hormone/parathyroid hormone-related peptide receptor
Human_gene_id： 5745
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5745
Human_swiss_prot_no： Q03431
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q03431/entry
Mouse_swiss_prot_no： P41593
Mouse_swiss_link： http://www.uniprot.org/uniprot/P41593
特異性： PTH/PTHrP-R Monoclonal Antibody detects endogenous levels of PTH/PTHrP-R protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor
信號(hào)通路： Neuroactive ligand-receptor interaction;
功能： disease:Defects in PTH1R are a cause of primary failure of tooth eruption (PFE) [MIM:125350]. PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.,disease:Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD) [MIM:215045]. BOCD is a severe skeletal dysplasia.,disease:Defects in PTH1R are the cause of Eiken syndrome [MIM:600002]; also called Eiken skeletal dysplasia or bone modeling defect of hands and feet. Eiken syndrome is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.,disease:Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC) [MIM:156400]. JMC is a rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.,disease:Defects in PTH1R may be a cause of enchondromatosis [MIM:166000]. Enchondromas are common benign cartilage tumors of bone. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.,function:This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Expressed in most tissues. Most abundant in kidney, bone and liver.,
相關(guān)產(chǎn)品： YT5856,YT3898,YM0542,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cell membrane ; Multi-pass membrane protein .
組織表達(dá)： Expressed in most tissues. Most abundant in kidney, bone and liver.
科研貨號(hào)： PLA005004

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