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PERK Monoclonal Antibody

商品貨號： PLA004987

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： EIF2AK3
蛋白名稱： Eukaryotic translation initiation factor 2-alpha kinase 3
Human_gene_id： 9451
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9451
Human_swiss_prot_no： Q9NZJ5
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9NZJ5/entry
Mouse_swiss_prot_no： Q9Z2B5
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z2B5
特異性： PERK Monoclonal Antibody detects endogenous levels of PERK protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
信號通路： Alzheimer's disease;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) [MIM:226980]; also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.,domain:The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.,enzyme regulation:Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction.,function:Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.,induction:By ER stress.,PTM:Autophosphorylated.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.,tissue specificity:Ubiquitous. A high level expression is seen in secretory tissues.,
相關(guān)產(chǎn)品： YT6126,YT3667,YT3666,YP1055,KA4229C
細胞定位： Endoplasmic reticulum membrane; Single-pass type I membrane protein.
組織表達： Ubiquitous. A high level expression is seen in secretory tissues.
科研貨號： PLA004987

PERK Monoclonal Antibody

Catalog No PLA004987

Product information

發(fā)貨日期： 7
基因名稱： EIF2AK3
蛋白名稱： Eukaryotic translation initiation factor 2-alpha kinase 3
Human_gene_id： 9451
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9451
Human_swiss_prot_no： Q9NZJ5
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9NZJ5/entry
Mouse_swiss_prot_no： Q9Z2B5
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z2B5
特異性： PERK Monoclonal Antibody detects endogenous levels of PERK protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
信號通路： Alzheimer's disease;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) [MIM:226980]; also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.,domain:The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.,enzyme regulation:Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction.,function:Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.,induction:By ER stress.,PTM:Autophosphorylated.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.,tissue specificity:Ubiquitous. A high level expression is seen in secretory tissues.,
相關(guān)產(chǎn)品： YT6126,YT3667,YT3666,YP1055,KA4229C
細胞定位： Endoplasmic reticulum membrane; Single-pass type I membrane protein.
組織表達： Ubiquitous. A high level expression is seen in secretory tissues.
科研貨號： PLA004987

Hunan UPT Biotechnology Co.,Ltd

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