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Pax-4 Monoclonal Antibody

商品貨號： PLA004979

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： PAX4
蛋白名稱： Paired box protein Pax-4
Human_gene_id： 5078
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5078
Human_swiss_prot_no： O43316
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43316/entry
Mouse_swiss_prot_no： P32115
Mouse_swiss_link： http://www.uniprot.org/uniprot/P32115
特異性： Pax-4 Monoclonal Antibody detects endogenous levels of Pax-4 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PAX4; Paired box protein Pax-4
信號通路： Maturity onset diabetes of the young;
功能： disease:Defects in PAX4 are a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2 or maturity-onset diabetes. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.,disease:Defects in PAX4 are the cause of maturity-onset diabetes of the young type 9 (MODY9) [MIM:612225]. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.,disease:Genetic variations in PAX4 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.,disease:Genetic variations in PAX4 are associated with susceptibility to ketosis-prone diabetes mellitus (KPD) [MIM:612227]. KPD belongs to a rare subgroup of type 2 diabetes with severe insulin deficiency, mostly observed in subjects of sub-Saharan African ancestry, such as west Africans, Caribbeans and African-Americans. Its phenotype is distinct from the common type 2 and type 1 diabetes. It is characterized by a fulminant initial insulin dependence, without the immunological markers observed in classical type 1 diabetes, followed by a subsequent clinical course which varies from non-insulin treated type 2 diabetes to insulin-dependent idiopathic type 1 diabetes. A severe dysfunction of the insulin-producing beta-cells is attested to by the observation that 25% of the subjects are insulin dependent at diabetes onset, whereas the remaining 75% will develop permanent insulin dependence within 10 years.,function:Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. The Pax4v isoform appears to be a dominant negative form antagonizing PAX4 transcriptional activity.,sequence caution:According to the human genome assembly there is a stop codon in position 349.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 paired domain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus.
組織表達： Colon,Insulinoma,PCR rescued clones,Placenta,
科研貨號： PLA004979

Pax-4 Monoclonal Antibody

Catalog No PLA004979

Product information

發(fā)貨日期： 7
基因名稱： PAX4
蛋白名稱： Paired box protein Pax-4
Human_gene_id： 5078
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5078
Human_swiss_prot_no： O43316
Human_swiss_link： http://www.uniprot.org/uniprotkb/O43316/entry
Mouse_swiss_prot_no： P32115
Mouse_swiss_link： http://www.uniprot.org/uniprot/P32115
特異性： Pax-4 Monoclonal Antibody detects endogenous levels of Pax-4 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PAX4; Paired box protein Pax-4
信號通路： Maturity onset diabetes of the young;
功能： disease:Defects in PAX4 are a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2 or maturity-onset diabetes. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.,disease:Defects in PAX4 are the cause of maturity-onset diabetes of the young type 9 (MODY9) [MIM:612225]. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.,disease:Genetic variations in PAX4 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.,disease:Genetic variations in PAX4 are associated with susceptibility to ketosis-prone diabetes mellitus (KPD) [MIM:612227]. KPD belongs to a rare subgroup of type 2 diabetes with severe insulin deficiency, mostly observed in subjects of sub-Saharan African ancestry, such as west Africans, Caribbeans and African-Americans. Its phenotype is distinct from the common type 2 and type 1 diabetes. It is characterized by a fulminant initial insulin dependence, without the immunological markers observed in classical type 1 diabetes, followed by a subsequent clinical course which varies from non-insulin treated type 2 diabetes to insulin-dependent idiopathic type 1 diabetes. A severe dysfunction of the insulin-producing beta-cells is attested to by the observation that 25% of the subjects are insulin dependent at diabetes onset, whereas the remaining 75% will develop permanent insulin dependence within 10 years.,function:Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. The Pax4v isoform appears to be a dominant negative form antagonizing PAX4 transcriptional activity.,sequence caution:According to the human genome assembly there is a stop codon in position 349.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 paired domain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus.
組織表達： Colon,Insulinoma,PCR rescued clones,Placenta,
科研貨號： PLA004979

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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