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PARP-1 Monoclonal Antibody

商品貨號： PLA004978

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： PARP1
蛋白名稱： Poly [ADP-ribose] polymerase 1
Human_gene_id： 142
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=142
Human_swiss_prot_no： P09874
Human_swiss_link： http://www.uniprot.org/uniprotkb/P09874/entry
Mouse_swiss_prot_no： P11103
Mouse_swiss_link： http://www.uniprot.org/uniprot/P11103
特異性： PARP-1 Monoclonal Antibody detects endogenous levels of PARP-1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
信號通路： Base excision repair;
功能： catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,miscellaneous:The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.,PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Poly-ADP-ribosylated by PARP2.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 2 PARP-type zinc fingers.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423.,
相關(guān)產(chǎn)品： YT5695,YM3145,YM3132,YM3131,YK0091,YC0101,YC0073,KA3972C,KA3971C
細(xì)胞定位： Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
組織表達(dá)： Brain,Colon carcinoma,Fibroblast,Lung,Ovarian carcinoma,Skin,
科研貨號： PLA004978

PARP-1 Monoclonal Antibody

Catalog No PLA004978

Product information

發(fā)貨日期： 7
基因名稱： PARP1
蛋白名稱： Poly [ADP-ribose] polymerase 1
Human_gene_id： 142
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=142
Human_swiss_prot_no： P09874
Human_swiss_link： http://www.uniprot.org/uniprotkb/P09874/entry
Mouse_swiss_prot_no： P11103
Mouse_swiss_link： http://www.uniprot.org/uniprot/P11103
特異性： PARP-1 Monoclonal Antibody detects endogenous levels of PARP-1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
信號通路： Base excision repair;
功能： catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,miscellaneous:The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.,PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Poly-ADP-ribosylated by PARP2.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 2 PARP-type zinc fingers.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423.,
相關(guān)產(chǎn)品： YT5695,YM3145,YM3132,YM3131,YK0091,YC0101,YC0073,KA3972C,KA3971C
細(xì)胞定位： Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
組織表達(dá)： Brain,Colon carcinoma,Fibroblast,Lung,Ovarian carcinoma,Skin,
科研貨號： PLA004978

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.