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N-CoR Monoclonal Antibody

商品貨號： PLA004952

適應性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： NCOR1
蛋白名稱： Nuclear receptor corepressor 1
Human_gene_id： 9611
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9611
Human_swiss_prot_no： O75376
Human_swiss_link： http://www.uniprot.org/uniprotkb/O75376/entry
Mouse_swiss_prot_no： Q60974
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60974
特異性： N-CoR Monoclonal Antibody detects endogenous levels of N-CoR protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1
功能： domain:The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.,domain:The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).,function:Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the N-CoR nuclear receptor corepressors family.,similarity:Contains 2 SANT domains.,subunit:Interacts with SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and MJD2A/JHDM3A. Interacts with ZBTB33/KAISO, and this interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with the catalytic domain of HDAC9. Interacts with CBFA2T3 and HEXIM1. Interacts with C1D.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus .
組織表達： Brain,Colon,Epithelium,Fetal brain,Lung,Ovary,Pancreas,Pooled,Skin,Testis,
科研貨號： PLA004952

N-CoR Monoclonal Antibody

Catalog No PLA004952

Product information

發(fā)貨日期： 7
基因名稱： NCOR1
蛋白名稱： Nuclear receptor corepressor 1
Human_gene_id： 9611
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9611
Human_swiss_prot_no： O75376
Human_swiss_link： http://www.uniprot.org/uniprotkb/O75376/entry
Mouse_swiss_prot_no： Q60974
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60974
特異性： N-CoR Monoclonal Antibody detects endogenous levels of N-CoR protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1
功能： domain:The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.,domain:The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).,function:Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the N-CoR nuclear receptor corepressors family.,similarity:Contains 2 SANT domains.,subunit:Interacts with SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and MJD2A/JHDM3A. Interacts with ZBTB33/KAISO, and this interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with the catalytic domain of HDAC9. Interacts with CBFA2T3 and HEXIM1. Interacts with C1D.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus .
組織表達： Brain,Colon,Epithelium,Fetal brain,Lung,Ovary,Pancreas,Pooled,Skin,Testis,
科研貨號： PLA004952

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

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Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.