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MTHFR Monoclonal Antibody

商品貨號(hào)： PLA004943

適應(yīng) 性： 人,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 7
基因名稱： MTHFR
蛋白名稱： Methylenetetrahydrofolate reductase
Human_gene_id： 4524
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4524
Human_swiss_prot_no： P42898
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42898/entry
Mouse_swiss_prot_no： Q9WU20
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WU20
特異性： MTHFR Monoclonal Antibody detects endogenous levels of MTHFR protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： MTHFR; Methylenetetrahydrofolate reductase
信號(hào)通路： One carbon pool by folate;Methane metabolism;
功能： catalytic activity:5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.,cofactor:FAD.,disease:Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.,disease:Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.,disease:Defects in MTHFR may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,enzyme regulation:Allosterically regulated by S-adenosylmethionine.,function:Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.,online information:Methylenetetrahydrofolate reductase entry,online information:The Singapore human mutation and polymorphism database,pathway:One-carbon metabolism; tetrahydrofolate pathway.,polymorphism:Genetic variation in MTHFR influences susceptibility to occlusive vascular disease, neural tube defects (NTD), colon cancer and acute leukemia.,similarity:Belongs to the methylenetetrahydrofolate reductase family.,subunit:Homodimer.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： cytosol,synapse,
組織表達(dá)： Brain,Liver,Lung,
科研貨號(hào)： PLA004943

MTHFR Monoclonal Antibody

Catalog No PLA004943

Product information

發(fā)貨日期： 7
基因名稱： MTHFR
蛋白名稱： Methylenetetrahydrofolate reductase
Human_gene_id： 4524
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4524
Human_swiss_prot_no： P42898
Human_swiss_link： http://www.uniprot.org/uniprotkb/P42898/entry
Mouse_swiss_prot_no： Q9WU20
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WU20
特異性： MTHFR Monoclonal Antibody detects endogenous levels of MTHFR protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： MTHFR; Methylenetetrahydrofolate reductase
信號(hào)通路： One carbon pool by folate;Methane metabolism;
功能： catalytic activity:5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.,cofactor:FAD.,disease:Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.,disease:Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.,disease:Defects in MTHFR may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,enzyme regulation:Allosterically regulated by S-adenosylmethionine.,function:Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.,online information:Methylenetetrahydrofolate reductase entry,online information:The Singapore human mutation and polymorphism database,pathway:One-carbon metabolism; tetrahydrofolate pathway.,polymorphism:Genetic variation in MTHFR influences susceptibility to occlusive vascular disease, neural tube defects (NTD), colon cancer and acute leukemia.,similarity:Belongs to the methylenetetrahydrofolate reductase family.,subunit:Homodimer.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： cytosol,synapse,
組織表達(dá)： Brain,Liver,Lung,
科研貨號(hào)： PLA004943

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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