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LKB1 Monoclonal Antibody

商品貨號： PLA004914

適應性： 人,小鼠,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： STK11
蛋白名稱： Serine/threonine-protein kinase 11
Human_gene_id： 6794
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6794
Human_swiss_prot_no： Q15831
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15831/entry
Mouse_gene_id： 20869
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20869
Mouse_swiss_prot_no： Q9WTK7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WTK7
特異性： LKB1 Monoclonal Antibody detects endogenous levels of LKB1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
信號通路： Insulin Receptor; mTOR; AMPK
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,disease:Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.,disease:Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,enzyme regulation:Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.,function:Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.,online information:PJS entry,PTM:Phosphorylated by a cAMP-dependent protein kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.,subunit:Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP.,tissue specificity:Ubiquitously expressed. Strongest expression in testis and fetal liver.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
組織表達： Ubiquitously expressed. Strongest expression in testis and fetal liver.
tag： hot
科研貨號： PLA004914

LKB1 Monoclonal Antibody

Catalog No PLA004914

Product information

發(fā)貨日期： 7
基因名稱： STK11
蛋白名稱： Serine/threonine-protein kinase 11
Human_gene_id： 6794
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6794
Human_swiss_prot_no： Q15831
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15831/entry
Mouse_gene_id： 20869
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20869
Mouse_swiss_prot_no： Q9WTK7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WTK7
特異性： LKB1 Monoclonal Antibody detects endogenous levels of LKB1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
信號通路： Insulin Receptor; mTOR; AMPK
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,disease:Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.,disease:Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,enzyme regulation:Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.,function:Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.,online information:PJS entry,PTM:Phosphorylated by a cAMP-dependent protein kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.,subunit:Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP.,tissue specificity:Ubiquitously expressed. Strongest expression in testis and fetal liver.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
組織表達： Ubiquitously expressed. Strongest expression in testis and fetal liver.
tag： hot
科研貨號： PLA004914

Hunan UPT Biotechnology Co.,Ltd

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