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IRE1α Monoclonal Antibody

商品貨號(hào)： PLA004884

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱： ERN1
蛋白名稱： Serine/threonine-protein kinase/endoribonuclease IRE1
Human_gene_id： 2081
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2081
Human_swiss_prot_no： O75460
Human_swiss_link： http://www.uniprot.org/uniprotkb/O75460/entry
Mouse_swiss_prot_no： Q9EQY0
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9EQY0
特異性： IRE1α Monoclonal Antibody detects endogenous levels of IRE1α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
信號(hào)通路： Alzheimer's disease;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1.,tissue specificity:Ubiquitously expressed. High levels observed in pancreatic tissue.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
組織表達(dá)： Ubiquitously expressed. High levels observed in pancreatic tissue.
科研貨號(hào)： PLA004884

IRE1α Monoclonal Antibody

Catalog No PLA004884

Product information

發(fā)貨日期： 7
基因名稱： ERN1
蛋白名稱： Serine/threonine-protein kinase/endoribonuclease IRE1
Human_gene_id： 2081
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2081
Human_swiss_prot_no： O75460
Human_swiss_link： http://www.uniprot.org/uniprotkb/O75460/entry
Mouse_swiss_prot_no： Q9EQY0
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9EQY0
特異性： IRE1α Monoclonal Antibody detects endogenous levels of IRE1α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
信號(hào)通路： Alzheimer's disease;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1.,tissue specificity:Ubiquitously expressed. High levels observed in pancreatic tissue.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
組織表達(dá)： Ubiquitously expressed. High levels observed in pancreatic tissue.
科研貨號(hào)： PLA004884

Hunan UPT Biotechnology Co.,Ltd

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