信號通路： MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;
功能： function:The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.,miscellaneous:This protein binds heparin more strongly than does aFGF.,PTM:Several N-termini starting at positions 48, 54, 47 and 65 have been identified by direct sequencing.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the heparin-binding growth factors family.,subunit:Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.,tissue specificity:Expressed in granulosa and cumulus cells.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Secreted . Nucleus . Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). .
組織表達： Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
信號通路： MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;
功能： function:The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.,miscellaneous:This protein binds heparin more strongly than does aFGF.,PTM:Several N-termini starting at positions 48, 54, 47 and 65 have been identified by direct sequencing.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the heparin-binding growth factors family.,subunit:Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.,tissue specificity:Expressed in granulosa and cumulus cells.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Secreted . Nucleus . Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). .
組織表達： Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
tag： hot
科研貨號： PLA004801
Hunan UPT Biotechnology Co.,Ltd
Website：m.hyjdss.com Servive hotline :4006916686
E-mail：service@uptbio.com
Address：
Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road,
Yuelu District, Changsha City, Hunan Province, China.
在線咨詢
湘公網(wǎng)安備