功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.,disease:Overexpressed in a subset of human mammary tumors.,domain:The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.,function:Binds and is activated by neuregulins and NTAK.,PTM:Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4 and MUC1.,tissue specificity:Epithelial tissues and brain.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.,disease:Overexpressed in a subset of human mammary tumors.,domain:The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.,function:Binds and is activated by neuregulins and NTAK.,PTM:Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4 and MUC1.,tissue specificity:Epithelial tissues and brain.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： [Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
組織表達： Epithelial tissues and brain.
科研貨號： PLA004788
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