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BPTF Monoclonal Antibody

商品貨號： PLA004673

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： BPTF
蛋白名稱： Nucleosome-remodeling factor subunit BPTF
Human_gene_id： 2186
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2186
Human_swiss_prot_no： Q12830
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q12830/entry
特異性： BPTF Monoclonal Antibody detects endogenous levels of BPTF protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： BPTF; FAC1; FALZ; Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
功能： developmental stage:Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).,domain:The second PHD-type zinc finger mediates binding to histone H3-K4Me3.,function:Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.,miscellaneous:Highly susceptible to proteolysis.,PTM:Phosphorylation enhances DNA-binding. Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Several sequencing errors in the N-terminal part.,sequence caution:Several sequencing errors.,similarity:Belongs to the PBTF family.,similarity:Contains 1 bromo domain.,similarity:Contains 1 DDT domain.,similarity:Contains 2 PHD-type zinc fingers.,subcellular location:In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.,subunit:Interacts with MAZ. Interacts with KEAP1. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with histone H3-K4Me3 and to a lesser extent with histone H3-K4Me2.,tissue specificity:Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.
組織表達(dá)： Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
科研貨號： PLA004673

BPTF Monoclonal Antibody

Catalog No PLA004673

Product information

發(fā)貨日期： 7
基因名稱： BPTF
蛋白名稱： Nucleosome-remodeling factor subunit BPTF
Human_gene_id： 2186
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2186
Human_swiss_prot_no： Q12830
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q12830/entry
特異性： BPTF Monoclonal Antibody detects endogenous levels of BPTF protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： BPTF; FAC1; FALZ; Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
功能： developmental stage:Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).,domain:The second PHD-type zinc finger mediates binding to histone H3-K4Me3.,function:Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.,miscellaneous:Highly susceptible to proteolysis.,PTM:Phosphorylation enhances DNA-binding. Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Several sequencing errors in the N-terminal part.,sequence caution:Several sequencing errors.,similarity:Belongs to the PBTF family.,similarity:Contains 1 bromo domain.,similarity:Contains 1 DDT domain.,similarity:Contains 2 PHD-type zinc fingers.,subcellular location:In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.,subunit:Interacts with MAZ. Interacts with KEAP1. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with histone H3-K4Me3 and to a lesser extent with histone H3-K4Me2.,tissue specificity:Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.
組織表達(dá)： Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
科研貨號： PLA004673

Hunan UPT Biotechnology Co.,Ltd

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