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BMPR-II Monoclonal Antibody

商品貨號： PLA004670

適應性： 人,小鼠,大鼠,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： BMPR2
蛋白名稱： Bone morphogenetic protein receptor type-2
Human_gene_id： 659
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=659
Human_swiss_prot_no： Q13873
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13873/entry
Mouse_gene_id： 12168
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12168
Mouse_swiss_prot_no： O35607
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35607
特異性： BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： BMPR2; PPH1; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
信號通路： Cytokine-cytokine receptor interaction;TGF-beta;
功能： catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.,disease:Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in heart and liver.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cell membrane ; Single-pass type I membrane protein.
組織表達： Highly expressed in heart and liver.
科研貨號： PLA004670

BMPR-II Monoclonal Antibody

Catalog No PLA004670

Product information

發(fā)貨日期： 7
基因名稱： BMPR2
蛋白名稱： Bone morphogenetic protein receptor type-2
Human_gene_id： 659
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=659
Human_swiss_prot_no： Q13873
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13873/entry
Mouse_gene_id： 12168
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12168
Mouse_swiss_prot_no： O35607
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35607
特異性： BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： BMPR2; PPH1; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
信號通路： Cytokine-cytokine receptor interaction;TGF-beta;
功能： catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.,disease:Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in heart and liver.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cell membrane ; Single-pass type I membrane protein.
組織表達： Highly expressed in heart and liver.
科研貨號： PLA004670

Hunan UPT Biotechnology Co.,Ltd

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